Placenta hominis protects osteoporosis in ovariectomized rats

H. J. Chae; K. H. Choi; S. W. Chae; H. M. Kim; T. K. Shin; G. Y. Lee; G. S. Jeong; H. R. Park; H. I. Choi; S. B. Kim; S. K. Yoo; H. R. Kim

doi:10.1080/08923970600626197

Placenta hominis protects osteoporosis in ovariectomized rats

H. J. Chae
, K. H. Choi
, S. W. Chae
, H. M. Kim
, T. K. Shin
, G. Y. Lee
, G. S. Jeong
, H. R. Park
, H. I. Choi
, S. B. Kim
, S. K. Yoo
, H. R. Kim^*

^*Corresponding author for this work

Department of Pharmacy

Research output: Contribution to journal › Journal article › peer-review

7 Scopus citations

Abstract

In China, Japan, and Korea, placenta hominis extracts (PHEs) are used clinically for the treatment of osteoporosis. The anti-osteoporotic effect of PHEs was studied. The trabecular bone area and thickness in OVX rats decreased by 50% from those in sham-operated rats; these decreases were completely inhibited by administration of PHEs for 7 weeks. Osteoclast numbers and the osteoblast surface were enhanced in OVX rats, but PHEs had no effect on these phenomena. Serum phosphorus and alkaline phosphatase in OVX rats increased compared to those in sham-operated rats, but the increases were not affected by the administration of PHEs. Thyroxine (T₄) level was stimulated in OVX rats. The extracts inhibited the T₄ level in the OVX rats. These results strongly suggest that PHEs be effective in preventing the development of bone loss induced by OVX in rats.

Original language	English
Pages (from-to)	165-173
Number of pages	9
Journal	Immunopharmacology and Immunotoxicology
Volume	28
Issue number	1
DOIs	https://doi.org/10.1080/08923970600626197
State	Published - 2006.01

Keywords

Osteoblast
Osteoclast
Ovariectomy (OVX)
Placenta Hominis Extracts (PHEs)
Serum Biochemistry

Quacquarelli Symonds(QS) Subject Topics

Medicine
Pharmacy & Pharmacology
Biological Sciences

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10.1080/08923970600626197

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@article{5ebbfa4dd639436199d4710700fbc572,

title = "Placenta hominis protects osteoporosis in ovariectomized rats",

abstract = "In China, Japan, and Korea, placenta hominis extracts (PHEs) are used clinically for the treatment of osteoporosis. The anti-osteoporotic effect of PHEs was studied. The trabecular bone area and thickness in OVX rats decreased by 50\% from those in sham-operated rats; these decreases were completely inhibited by administration of PHEs for 7 weeks. Osteoclast numbers and the osteoblast surface were enhanced in OVX rats, but PHEs had no effect on these phenomena. Serum phosphorus and alkaline phosphatase in OVX rats increased compared to those in sham-operated rats, but the increases were not affected by the administration of PHEs. Thyroxine (T4) level was stimulated in OVX rats. The extracts inhibited the T4 level in the OVX rats. These results strongly suggest that PHEs be effective in preventing the development of bone loss induced by OVX in rats.",

keywords = "Osteoblast, Osteoclast, Ovariectomy (OVX), Placenta Hominis Extracts (PHEs), Serum Biochemistry",

author = "Chae, \{H. J.\} and Choi, \{K. H.\} and Chae, \{S. W.\} and Kim, \{H. M.\} and Shin, \{T. K.\} and Lee, \{G. Y.\} and Jeong, \{G. S.\} and Park, \{H. R.\} and Choi, \{H. I.\} and Kim, \{S. B.\} and Yoo, \{S. K.\} and Kim, \{H. R.\}",

year = "2006",

month = jan,

doi = "10.1080/08923970600626197",

language = "English",

volume = "28",

pages = "165--173",

journal = "Immunopharmacology and Immunotoxicology",

issn = "0892-3973",

number = "1",

}

TY - JOUR

T1 - Placenta hominis protects osteoporosis in ovariectomized rats

AU - Chae, H. J.

AU - Choi, K. H.

AU - Chae, S. W.

AU - Kim, H. M.

AU - Shin, T. K.

AU - Lee, G. Y.

AU - Jeong, G. S.

AU - Park, H. R.

AU - Choi, H. I.

AU - Kim, S. B.

AU - Yoo, S. K.

AU - Kim, H. R.

PY - 2006/1

Y1 - 2006/1

N2 - In China, Japan, and Korea, placenta hominis extracts (PHEs) are used clinically for the treatment of osteoporosis. The anti-osteoporotic effect of PHEs was studied. The trabecular bone area and thickness in OVX rats decreased by 50% from those in sham-operated rats; these decreases were completely inhibited by administration of PHEs for 7 weeks. Osteoclast numbers and the osteoblast surface were enhanced in OVX rats, but PHEs had no effect on these phenomena. Serum phosphorus and alkaline phosphatase in OVX rats increased compared to those in sham-operated rats, but the increases were not affected by the administration of PHEs. Thyroxine (T4) level was stimulated in OVX rats. The extracts inhibited the T4 level in the OVX rats. These results strongly suggest that PHEs be effective in preventing the development of bone loss induced by OVX in rats.

AB - In China, Japan, and Korea, placenta hominis extracts (PHEs) are used clinically for the treatment of osteoporosis. The anti-osteoporotic effect of PHEs was studied. The trabecular bone area and thickness in OVX rats decreased by 50% from those in sham-operated rats; these decreases were completely inhibited by administration of PHEs for 7 weeks. Osteoclast numbers and the osteoblast surface were enhanced in OVX rats, but PHEs had no effect on these phenomena. Serum phosphorus and alkaline phosphatase in OVX rats increased compared to those in sham-operated rats, but the increases were not affected by the administration of PHEs. Thyroxine (T4) level was stimulated in OVX rats. The extracts inhibited the T4 level in the OVX rats. These results strongly suggest that PHEs be effective in preventing the development of bone loss induced by OVX in rats.

KW - Osteoblast

KW - Osteoclast

KW - Ovariectomy (OVX)

KW - Placenta Hominis Extracts (PHEs)

KW - Serum Biochemistry

UR - https://www.scopus.com/pages/publications/33646689123

U2 - 10.1080/08923970600626197

DO - 10.1080/08923970600626197

M3 - Journal article

C2 - 16684675

AN - SCOPUS:33646689123

SN - 0892-3973

VL - 28

SP - 165

EP - 173

JO - Immunopharmacology and Immunotoxicology

JF - Immunopharmacology and Immunotoxicology

IS - 1

ER -

Placenta hominis protects osteoporosis in ovariectomized rats

Abstract

Keywords

Quacquarelli Symonds(QS) Subject Topics

Access to Document

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