Polychlorinated compounds with PPAR-γ agonistic effect from the medicinal fungus Phellinus ribis

In Kyoung Lee; Jeong Hyung Lee; Bong Sik Yun

doi:10.1016/j.bmcl.2008.07.034

Polychlorinated compounds with PPAR-γ agonistic effect from the medicinal fungus Phellinus ribis

In Kyoung Lee
, Jeong Hyung Lee
, Bong Sik Yun^*

^*Corresponding author for this work

Environmental Biotechnology

Korea Research Institute of Bioscience and Biotechnology
Kangwon National University

Research output: Contribution to journal › Journal article › peer-review

49 Scopus citations

Abstract

During the search for natural substances with PPAR-γ agonistic effect, unique polychlorinated compounds named chlorophellins A-C have been isolated together with the known compound, drosophilin A, from the methanolic extract of the fruiting body of the fungus Phellinus ribis. Their structures were assigned on the basis of NMR and mass spectrometric analyses. Chlorophellin C of compounds tested exhibited the most potent PPAR-γ agonistic effect and was comparable to rosiglitazone, a well-known PPAR-γ agonist that has been used for the therapy of type 2 diabetes.

Original language	English
Pages (from-to)	4566-4568
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	18
Issue number	16
DOIs	https://doi.org/10.1016/j.bmcl.2008.07.034
State	Published - 2008.08.15

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Chlorophellins
Phellinus ribis
Polychlorinated compounds
PPAR-γ

Access to Document

10.1016/j.bmcl.2008.07.034

Cite this

@article{043b911feaf54a14b744aed7b1fec213,

title = "Polychlorinated compounds with PPAR-γ agonistic effect from the medicinal fungus Phellinus ribis",

abstract = "During the search for natural substances with PPAR-γ agonistic effect, unique polychlorinated compounds named chlorophellins A-C have been isolated together with the known compound, drosophilin A, from the methanolic extract of the fruiting body of the fungus Phellinus ribis. Their structures were assigned on the basis of NMR and mass spectrometric analyses. Chlorophellin C of compounds tested exhibited the most potent PPAR-γ agonistic effect and was comparable to rosiglitazone, a well-known PPAR-γ agonist that has been used for the therapy of type 2 diabetes.",

keywords = "Chlorophellins, Phellinus ribis, Polychlorinated compounds, PPAR-γ",

author = "Lee, \{In Kyoung\} and Lee, \{Jeong Hyung\} and Yun, \{Bong Sik\}",

year = "2008",

month = aug,

day = "15",

doi = "10.1016/j.bmcl.2008.07.034",

language = "English",

volume = "18",

pages = "4566--4568",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

number = "16",

}

TY - JOUR

T1 - Polychlorinated compounds with PPAR-γ agonistic effect from the medicinal fungus Phellinus ribis

AU - Lee, In Kyoung

AU - Lee, Jeong Hyung

AU - Yun, Bong Sik

PY - 2008/8/15

Y1 - 2008/8/15

N2 - During the search for natural substances with PPAR-γ agonistic effect, unique polychlorinated compounds named chlorophellins A-C have been isolated together with the known compound, drosophilin A, from the methanolic extract of the fruiting body of the fungus Phellinus ribis. Their structures were assigned on the basis of NMR and mass spectrometric analyses. Chlorophellin C of compounds tested exhibited the most potent PPAR-γ agonistic effect and was comparable to rosiglitazone, a well-known PPAR-γ agonist that has been used for the therapy of type 2 diabetes.

AB - During the search for natural substances with PPAR-γ agonistic effect, unique polychlorinated compounds named chlorophellins A-C have been isolated together with the known compound, drosophilin A, from the methanolic extract of the fruiting body of the fungus Phellinus ribis. Their structures were assigned on the basis of NMR and mass spectrometric analyses. Chlorophellin C of compounds tested exhibited the most potent PPAR-γ agonistic effect and was comparable to rosiglitazone, a well-known PPAR-γ agonist that has been used for the therapy of type 2 diabetes.

KW - Chlorophellins

KW - Phellinus ribis

KW - Polychlorinated compounds

KW - PPAR-γ

UR - https://www.scopus.com/pages/publications/48849095164

U2 - 10.1016/j.bmcl.2008.07.034

DO - 10.1016/j.bmcl.2008.07.034

M3 - Journal article

C2 - 18667308

AN - SCOPUS:48849095164

SN - 0960-894X

VL - 18

SP - 4566

EP - 4568

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 16

ER -

Polychlorinated compounds with PPAR-γ agonistic effect from the medicinal fungus Phellinus ribis

Abstract

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Cite this