Polymerase-mediated synthesis ofp-vinylaniline-coupled fluorescent DNA for the sensing of nucleolin protein-c-mycG-quadruplex interactions

Guralamatta Siddappa Ravi Kumara; Young Jun Seo

doi:10.1039/d1ob00863c

Polymerase-mediated synthesis ofp-vinylaniline-coupled fluorescent DNA for the sensing of nucleolin protein-c-mycG-quadruplex interactions

Guralamatta Siddappa Ravi Kumara
, Young Jun Seo^*

^*Corresponding author for this work

Department of Chemistry

Jeonbuk National University

Research output: Contribution to journal › Journal article › peer-review

7 Scopus citations

Abstract

In this paper we report the synthesis of two deoxyuridine derivatives (dU_CN2,dU_Py)—featuringp-vinylaniline-based fluorophores linked through a propargyl unit at the 5′ position—that function as molecular rotors. This probing system proved to be useful for the sensing of gene regulation arising from interactions between this G-quadruplex and nucleolin.

Original language	English
Pages (from-to)	5788-5793
Number of pages	6
Journal	Organic and Biomolecular Chemistry
Volume	19
Issue number	26
DOIs	https://doi.org/10.1039/d1ob00863c
State	Published - 2021.07.14

Quacquarelli Symonds(QS) Subject Topics

Engineering - Petroleum
Chemistry
Biological Sciences

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title = "Polymerase-mediated synthesis ofp-vinylaniline-coupled fluorescent DNA for the sensing of nucleolin protein-c-mycG-quadruplex interactions",

abstract = "In this paper we report the synthesis of two deoxyuridine derivatives (dUCN2,dUPy)—featuringp-vinylaniline-based fluorophores linked through a propargyl unit at the 5′ position—that function as molecular rotors. This probing system proved to be useful for the sensing of gene regulation arising from interactions between this G-quadruplex and nucleolin.",

author = "\{Ravi Kumara\}, \{Guralamatta Siddappa\} and Seo, \{Young Jun\}",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2021.",

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doi = "10.1039/d1ob00863c",

language = "English",

volume = "19",

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T1 - Polymerase-mediated synthesis ofp-vinylaniline-coupled fluorescent DNA for the sensing of nucleolin protein-c-mycG-quadruplex interactions

AU - Ravi Kumara, Guralamatta Siddappa

AU - Seo, Young Jun

N1 - Publisher Copyright: © The Royal Society of Chemistry 2021.

PY - 2021/7/14

Y1 - 2021/7/14

N2 - In this paper we report the synthesis of two deoxyuridine derivatives (dUCN2,dUPy)—featuringp-vinylaniline-based fluorophores linked through a propargyl unit at the 5′ position—that function as molecular rotors. This probing system proved to be useful for the sensing of gene regulation arising from interactions between this G-quadruplex and nucleolin.

AB - In this paper we report the synthesis of two deoxyuridine derivatives (dUCN2,dUPy)—featuringp-vinylaniline-based fluorophores linked through a propargyl unit at the 5′ position—that function as molecular rotors. This probing system proved to be useful for the sensing of gene regulation arising from interactions between this G-quadruplex and nucleolin.

UR - https://www.scopus.com/pages/publications/85109284795

U2 - 10.1039/d1ob00863c

DO - 10.1039/d1ob00863c

M3 - Journal article

C2 - 34085078

AN - SCOPUS:85109284795

SN - 1477-0520

VL - 19

SP - 5788

EP - 5793

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 26

ER -

Polymerase-mediated synthesis ofp-vinylaniline-coupled fluorescent DNA for the sensing of nucleolin protein-c-mycG-quadruplex interactions

Abstract

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