Polymeric nano-micelles using poly(ethylene glycol) and poly(trimethylene carbonate) diblock copolymers as a drug carrier

Hoon Hyun; Jung Won Lee; Jae Song Cho; Yu Han Kim; Chang Rae Lee; Moon Suk Kim; Gilson Khang; Hai Bang Lee

doi:10.1016/j.colsurfa.2007.05.078

Polymeric nano-micelles using poly(ethylene glycol) and poly(trimethylene carbonate) diblock copolymers as a drug carrier

Hoon Hyun
, Jung Won Lee
, Jae Song Cho
, Yu Han Kim
, Chang Rae Lee
, Moon Suk Kim^*
, Gilson Khang
, Hai Bang Lee

^*Corresponding author for this work

Department of Polymer -Nano Science &Technology

Research output: Contribution to journal › Journal article › peer-review

15 Scopus citations

Abstract

The polymerization of trimethylene carbonate (TMC) in the presence of HCl·Et₂O via activated monomer mechanism was performed to synthesize diblock copolymers composed of methoxy poly(ethylene glycol) (MPEG) and poly(trimethylene carbonate) (PTMC). The obtained PTMCs had molecular weights close to the theoretical values calculated from the TMC to MPEG molar ratios and exhibited monomodal GPC curves. We successfully prepared MPEG and PTMC diblock copolymers by activated monomer mechanism. The micellar characterization of MPEG-PTMC diblock copolymers in an aqueous phase was carried out by using NMR, dynamic light scattering, AFM and fluorescence techniques. The diblock copolymers formed micelles with a critical micelle concentration (CMC) ranging 1.76 × 10^-3 to 0.79 × 10^-3 mg/mL, depended on the hydrophobic block lengths of MPEG-PTMC copolymers. The diameters of micelles, measured by dynamic light scattering, were 150-360 nm. Most micelles exhibited a spherical shape in AFM.

Original language	English
Pages (from-to)	131-135
Number of pages	5
Journal	Colloids and Surfaces A: Physicochemical and Engineering Aspects
Volume	313-314
DOIs	https://doi.org/10.1016/j.colsurfa.2007.05.078
State	Published - 2008.02.1

Keywords

Block copolymers
Critical micelle concentration
Micelles
Poly(ethylene glycol)
Poly(trimethylene carbonate)
Ring-opening polymerization

Quacquarelli Symonds(QS) Subject Topics

Engineering - Petroleum
Engineering - Chemical
Chemistry
Physics & Astronomy

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10.1016/j.colsurfa.2007.05.078

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@article{f63986dabb974bf98b86ed5ed4e302e0,

title = "Polymeric nano-micelles using poly(ethylene glycol) and poly(trimethylene carbonate) diblock copolymers as a drug carrier",

abstract = "The polymerization of trimethylene carbonate (TMC) in the presence of HCl·Et2O via activated monomer mechanism was performed to synthesize diblock copolymers composed of methoxy poly(ethylene glycol) (MPEG) and poly(trimethylene carbonate) (PTMC). The obtained PTMCs had molecular weights close to the theoretical values calculated from the TMC to MPEG molar ratios and exhibited monomodal GPC curves. We successfully prepared MPEG and PTMC diblock copolymers by activated monomer mechanism. The micellar characterization of MPEG-PTMC diblock copolymers in an aqueous phase was carried out by using NMR, dynamic light scattering, AFM and fluorescence techniques. The diblock copolymers formed micelles with a critical micelle concentration (CMC) ranging 1.76 × 10-3 to 0.79 × 10-3 mg/mL, depended on the hydrophobic block lengths of MPEG-PTMC copolymers. The diameters of micelles, measured by dynamic light scattering, were 150-360 nm. Most micelles exhibited a spherical shape in AFM.",

keywords = "Block copolymers, Critical micelle concentration, Micelles, Poly(ethylene glycol), Poly(trimethylene carbonate), Ring-opening polymerization",

author = "Hoon Hyun and Lee, \{Jung Won\} and Cho, \{Jae Song\} and Kim, \{Yu Han\} and Lee, \{Chang Rae\} and Kim, \{Moon Suk\} and Gilson Khang and Lee, \{Hai Bang\}",

year = "2008",

month = feb,

day = "1",

doi = "10.1016/j.colsurfa.2007.05.078",

language = "English",

volume = "313-314",

pages = "131--135",

journal = "Colloids and Surfaces A: Physicochemical and Engineering Aspects",

issn = "0927-7757",

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TY - JOUR

T1 - Polymeric nano-micelles using poly(ethylene glycol) and poly(trimethylene carbonate) diblock copolymers as a drug carrier

AU - Hyun, Hoon

AU - Lee, Jung Won

AU - Cho, Jae Song

AU - Kim, Yu Han

AU - Lee, Chang Rae

AU - Kim, Moon Suk

AU - Khang, Gilson

AU - Lee, Hai Bang

PY - 2008/2/1

Y1 - 2008/2/1

N2 - The polymerization of trimethylene carbonate (TMC) in the presence of HCl·Et2O via activated monomer mechanism was performed to synthesize diblock copolymers composed of methoxy poly(ethylene glycol) (MPEG) and poly(trimethylene carbonate) (PTMC). The obtained PTMCs had molecular weights close to the theoretical values calculated from the TMC to MPEG molar ratios and exhibited monomodal GPC curves. We successfully prepared MPEG and PTMC diblock copolymers by activated monomer mechanism. The micellar characterization of MPEG-PTMC diblock copolymers in an aqueous phase was carried out by using NMR, dynamic light scattering, AFM and fluorescence techniques. The diblock copolymers formed micelles with a critical micelle concentration (CMC) ranging 1.76 × 10-3 to 0.79 × 10-3 mg/mL, depended on the hydrophobic block lengths of MPEG-PTMC copolymers. The diameters of micelles, measured by dynamic light scattering, were 150-360 nm. Most micelles exhibited a spherical shape in AFM.

AB - The polymerization of trimethylene carbonate (TMC) in the presence of HCl·Et2O via activated monomer mechanism was performed to synthesize diblock copolymers composed of methoxy poly(ethylene glycol) (MPEG) and poly(trimethylene carbonate) (PTMC). The obtained PTMCs had molecular weights close to the theoretical values calculated from the TMC to MPEG molar ratios and exhibited monomodal GPC curves. We successfully prepared MPEG and PTMC diblock copolymers by activated monomer mechanism. The micellar characterization of MPEG-PTMC diblock copolymers in an aqueous phase was carried out by using NMR, dynamic light scattering, AFM and fluorescence techniques. The diblock copolymers formed micelles with a critical micelle concentration (CMC) ranging 1.76 × 10-3 to 0.79 × 10-3 mg/mL, depended on the hydrophobic block lengths of MPEG-PTMC copolymers. The diameters of micelles, measured by dynamic light scattering, were 150-360 nm. Most micelles exhibited a spherical shape in AFM.

KW - Block copolymers

KW - Critical micelle concentration

KW - Micelles

KW - Poly(ethylene glycol)

KW - Poly(trimethylene carbonate)

KW - Ring-opening polymerization

UR - https://www.scopus.com/pages/publications/37349050275

U2 - 10.1016/j.colsurfa.2007.05.078

DO - 10.1016/j.colsurfa.2007.05.078

M3 - Journal article

AN - SCOPUS:37349050275

SN - 0927-7757

VL - 313-314

SP - 131

EP - 135

JO - Colloids and Surfaces A: Physicochemical and Engineering Aspects

JF - Colloids and Surfaces A: Physicochemical and Engineering Aspects

ER -

Polymeric nano-micelles using poly(ethylene glycol) and poly(trimethylene carbonate) diblock copolymers as a drug carrier

Abstract

Keywords

Quacquarelli Symonds(QS) Subject Topics

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