Polymorphism in the promoter region of SEMA5A is associated with sociality traits in Korean subjects with autism spectrum disorders

Soon Ae Kim; Boong Nyun Kim; Jae Won Kim; Min Sup Shin; Tae Won Park; Jung Woo Son; Un Sun Chung; Mira Park

doi:10.4306/pi.2017.14.6.876

Polymorphism in the promoter region of SEMA5A is associated with sociality traits in Korean subjects with autism spectrum disorders

Soon Ae Kim^*
, Boong Nyun Kim
, Jae Won Kim
, Min Sup Shin
, Tae Won Park
, Jung Woo Son
, Un Sun Chung
, Mira Park

^*Corresponding author for this work

Department of Medicine

Research output: Contribution to journal › Journal article › peer-review

6 Scopus citations

Abstract

In this study, we evaluated the association between autism spectrum disorders (ASDs) and 10 single-nucleotide polymorphisms (SNPs) in the 5’ region of the semaphorin 5A gene (SEMA5A) for 250 Korean trios including children with ASDs. Family-based association testing and haplotype analysis revealed a statistically significant association between rs194085 and multiple sociality traits with Korean ASDs in the dominant model (p<0.001, corrected p=0.035). This indicates that genetic variations in the 5’ region of SEMA5A play a role in the genetic predisposition to sociality traits in Korean ASDs.

Original language	English
Pages (from-to)	876-878
Number of pages	3
Journal	Psychiatry Investigation
Volume	14
Issue number	6
DOIs	https://doi.org/10.4306/pi.2017.14.6.876
State	Published - 2017.11

Keywords

Autism spectrum disorder
Polymorphism
Semaphorin 5A gene
Sociality

Quacquarelli Symonds(QS) Subject Topics

Medicine

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10.4306/pi.2017.14.6.876

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title = "Polymorphism in the promoter region of SEMA5A is associated with sociality traits in Korean subjects with autism spectrum disorders",

abstract = "In this study, we evaluated the association between autism spectrum disorders (ASDs) and 10 single-nucleotide polymorphisms (SNPs) in the 5{\textquoteright} region of the semaphorin 5A gene (SEMA5A) for 250 Korean trios including children with ASDs. Family-based association testing and haplotype analysis revealed a statistically significant association between rs194085 and multiple sociality traits with Korean ASDs in the dominant model (p<0.001, corrected p=0.035). This indicates that genetic variations in the 5{\textquoteright} region of SEMA5A play a role in the genetic predisposition to sociality traits in Korean ASDs.",

keywords = "Autism spectrum disorder, Polymorphism, Semaphorin 5A gene, Sociality",

author = "Kim, \{Soon Ae\} and Kim, \{Boong Nyun\} and Kim, \{Jae Won\} and Shin, \{Min Sup\} and Park, \{Tae Won\} and Son, \{Jung Woo\} and Chung, \{Un Sun\} and Mira Park",

note = "Publisher Copyright: {\textcopyright} 2017 Korean Neuropsychiatric Association.",

year = "2017",

month = nov,

doi = "10.4306/pi.2017.14.6.876",

language = "English",

volume = "14",

pages = "876--878",

journal = "Psychiatry Investigation",

issn = "1738-3684",

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}

TY - JOUR

T1 - Polymorphism in the promoter region of SEMA5A is associated with sociality traits in Korean subjects with autism spectrum disorders

AU - Kim, Soon Ae

AU - Kim, Boong Nyun

AU - Kim, Jae Won

AU - Shin, Min Sup

AU - Park, Tae Won

AU - Son, Jung Woo

AU - Chung, Un Sun

AU - Park, Mira

PY - 2017/11

Y1 - 2017/11

N2 - In this study, we evaluated the association between autism spectrum disorders (ASDs) and 10 single-nucleotide polymorphisms (SNPs) in the 5’ region of the semaphorin 5A gene (SEMA5A) for 250 Korean trios including children with ASDs. Family-based association testing and haplotype analysis revealed a statistically significant association between rs194085 and multiple sociality traits with Korean ASDs in the dominant model (p<0.001, corrected p=0.035). This indicates that genetic variations in the 5’ region of SEMA5A play a role in the genetic predisposition to sociality traits in Korean ASDs.

AB - In this study, we evaluated the association between autism spectrum disorders (ASDs) and 10 single-nucleotide polymorphisms (SNPs) in the 5’ region of the semaphorin 5A gene (SEMA5A) for 250 Korean trios including children with ASDs. Family-based association testing and haplotype analysis revealed a statistically significant association between rs194085 and multiple sociality traits with Korean ASDs in the dominant model (p<0.001, corrected p=0.035). This indicates that genetic variations in the 5’ region of SEMA5A play a role in the genetic predisposition to sociality traits in Korean ASDs.

KW - Autism spectrum disorder

KW - Polymorphism

KW - Semaphorin 5A gene

KW - Sociality

UR - https://www.scopus.com/pages/publications/85034238779

U2 - 10.4306/pi.2017.14.6.876

DO - 10.4306/pi.2017.14.6.876

M3 - Journal article

AN - SCOPUS:85034238779

SN - 1738-3684

VL - 14

SP - 876

EP - 878

JO - Psychiatry Investigation

JF - Psychiatry Investigation

IS - 6

ER -

Polymorphism in the promoter region of SEMA5A is associated with sociality traits in Korean subjects with autism spectrum disorders

Abstract

Keywords

Quacquarelli Symonds(QS) Subject Topics

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