Preparation and characterization of ibuprofen using self-emulsifying drug delivery system in vivo

Gilson Khang; Jae Chan Yang; Jong Tae Ko; Jung Soo Park; Moon Suk Kim; John M. Rhee; Hai Bang Lee

doi:10.4028/0-87849-436-7.541

Preparation and characterization of ibuprofen using self-emulsifying drug delivery system in vivo

Gilson Khang^*
, Jae Chan Yang
, Jong Tae Ko
, Jung Soo Park
, Moon Suk Kim
, John M. Rhee
, Hai Bang Lee

^*Corresponding author for this work

Department of Polymer -Nano Science &Technology

Jeonbuk National University
Korea Research Institute of Chemical Technology

Research output: Contribution to journal › Journal article › peer-review

2 Scopus citations

Abstract

Ibuprofen (IBU) is a non-steroidal anti-inflammatory drag to treat rheumatoid arthritis, fever and mild pain. However, IBU was very low solubility in water (0.03~2.5 mg/ml). A nanoemulsion containing IBU by means of self-microemulsifying drug delivery system (SMEDDS) was prepared to enhance the solubility of IBU. SMEDDS was composed of cosurfactant, oil and surfactant. The solubility in various components such as cosurfactant (Carbitol, 386.9±20.5 mg/ml), oil(Labrafil M1944CS, 90.16±1.6 mg/ml) and surfactant (Cremophor RH-40, 239.01±2.8 mg/ml) was tested, respectively. Optimized formulation of SMEDDS was obtained by phase diagram. SMEDDS containing IBU revealed higher dissolution rate and bioavailability than those of conventional IBU syrups.

Original language	English
Pages (from-to)	541-544
Number of pages	4
Journal	Key Engineering Materials
Volume	342-343
DOIs	https://doi.org/10.4028/0-87849-436-7.541
State	Published - 2007

Keywords

Bioavailability
Drug delivery system
Ibuprofen
Self-emulsifying

Quacquarelli Symonds(QS) Subject Topics

Engineering - Mechanical
Materials Science

Access to Document

10.4028/0-87849-436-7.541

Cite this

@article{c61c3c3a826944368989e01dc452170b,

title = "Preparation and characterization of ibuprofen using self-emulsifying drug delivery system in vivo",

abstract = "Ibuprofen (IBU) is a non-steroidal anti-inflammatory drag to treat rheumatoid arthritis, fever and mild pain. However, IBU was very low solubility in water (0.03\textasciitilde{}2.5 mg/ml). A nanoemulsion containing IBU by means of self-microemulsifying drug delivery system (SMEDDS) was prepared to enhance the solubility of IBU. SMEDDS was composed of cosurfactant, oil and surfactant. The solubility in various components such as cosurfactant (Carbitol, 386.9±20.5 mg/ml), oil(Labrafil M1944CS, 90.16±1.6 mg/ml) and surfactant (Cremophor RH-40, 239.01±2.8 mg/ml) was tested, respectively. Optimized formulation of SMEDDS was obtained by phase diagram. SMEDDS containing IBU revealed higher dissolution rate and bioavailability than those of conventional IBU syrups.",

keywords = "Bioavailability, Drug delivery system, Ibuprofen, Self-emulsifying",

author = "Gilson Khang and Yang, \{Jae Chan\} and Ko, \{Jong Tae\} and Park, \{Jung Soo\} and Kim, \{Moon Suk\} and Rhee, \{John M.\} and Lee, \{Hai Bang\}",

year = "2007",

doi = "10.4028/0-87849-436-7.541",

language = "English",

volume = "342-343",

pages = "541--544",

journal = "Key Engineering Materials",

issn = "1013-9826",

}

TY - JOUR

T1 - Preparation and characterization of ibuprofen using self-emulsifying drug delivery system in vivo

AU - Khang, Gilson

AU - Yang, Jae Chan

AU - Ko, Jong Tae

AU - Park, Jung Soo

AU - Kim, Moon Suk

AU - Rhee, John M.

AU - Lee, Hai Bang

PY - 2007

Y1 - 2007

N2 - Ibuprofen (IBU) is a non-steroidal anti-inflammatory drag to treat rheumatoid arthritis, fever and mild pain. However, IBU was very low solubility in water (0.03~2.5 mg/ml). A nanoemulsion containing IBU by means of self-microemulsifying drug delivery system (SMEDDS) was prepared to enhance the solubility of IBU. SMEDDS was composed of cosurfactant, oil and surfactant. The solubility in various components such as cosurfactant (Carbitol, 386.9±20.5 mg/ml), oil(Labrafil M1944CS, 90.16±1.6 mg/ml) and surfactant (Cremophor RH-40, 239.01±2.8 mg/ml) was tested, respectively. Optimized formulation of SMEDDS was obtained by phase diagram. SMEDDS containing IBU revealed higher dissolution rate and bioavailability than those of conventional IBU syrups.

AB - Ibuprofen (IBU) is a non-steroidal anti-inflammatory drag to treat rheumatoid arthritis, fever and mild pain. However, IBU was very low solubility in water (0.03~2.5 mg/ml). A nanoemulsion containing IBU by means of self-microemulsifying drug delivery system (SMEDDS) was prepared to enhance the solubility of IBU. SMEDDS was composed of cosurfactant, oil and surfactant. The solubility in various components such as cosurfactant (Carbitol, 386.9±20.5 mg/ml), oil(Labrafil M1944CS, 90.16±1.6 mg/ml) and surfactant (Cremophor RH-40, 239.01±2.8 mg/ml) was tested, respectively. Optimized formulation of SMEDDS was obtained by phase diagram. SMEDDS containing IBU revealed higher dissolution rate and bioavailability than those of conventional IBU syrups.

KW - Bioavailability

KW - Drug delivery system

KW - Ibuprofen

KW - Self-emulsifying

UR - https://www.scopus.com/pages/publications/34147117876

U2 - 10.4028/0-87849-436-7.541

DO - 10.4028/0-87849-436-7.541

M3 - Journal article

AN - SCOPUS:34147117876

SN - 1013-9826

VL - 342-343

SP - 541

EP - 544

JO - Key Engineering Materials

JF - Key Engineering Materials

ER -

Preparation and characterization of ibuprofen using self-emulsifying drug delivery system in vivo

Abstract

Keywords

Quacquarelli Symonds(QS) Subject Topics

Access to Document

Other files and links

Fingerprint

Cite this