Preparation and release behavior of atorvastatin calcuim - Encapsulated polyoxalate microspheres

Cheon Jung Lee; Su Young Kim; Hyun Gu Lee; Jaewon Yang; Jin Young Park; Se Rom Cha; Dong Kwon Lim; Dongwon Lee; Gilson Khang

doi:10.7317/pk.2014.38.5.656

Preparation and release behavior of atorvastatin calcuim - Encapsulated polyoxalate microspheres

Cheon Jung Lee
, Su Young Kim
, Hyun Gu Lee
, Jaewon Yang
, Jin Young Park
, Se Rom Cha
, Dong Kwon Lim
, Dongwon Lee
, Gilson Khang^*

^*Corresponding author for this work

Department of Polymer -Nano Science &Technology

Jeonbuk National University

Research output: Contribution to journal › Journal article › peer-review

4 Scopus citations

Abstract

Atorvastatin calcium-loaded polyoxalate (POX) microspheres were prepared by an emulsion solvent-evaporation/extraction method of oil-in-oil-in-water (O₁/O₂/W) for sustained release. We investigated the release behavior according to initial drug ratio, molecular weight (M_w) and concentration of POX and concentration of emulsifier. The microsphere was characterized on the surface, the cross-section morphology and the behavior of atorvastatin calcium release for 10 days by scanning electron microscopy (SEM) and high performance liquid chromatography (HPLC). The analysis of crystallization was analyzed to use X-ray diffraction (XRD), differential scanning calorimeter (DSC) and Fourier transform infrared (FTIR). These results showed that the release behaviors can be controlled by preparation conditions.

Original language	English
Pages (from-to)	656-663
Number of pages	8
Journal	Polymer (Korea)
Volume	38
Issue number	5
DOIs	https://doi.org/10.7317/pk.2014.38.5.656
State	Published - 2014.09.1

Keywords

Atorvastatin calcium
Controlled release
Microsphere
O/O/W
Polyoxalate

Quacquarelli Symonds(QS) Subject Topics

Materials Science
Engineering - Chemical

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10.7317/pk.2014.38.5.656

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@article{e0b265ccb6da467bbea1a07e32c26f0e,

title = "Preparation and release behavior of atorvastatin calcuim - Encapsulated polyoxalate microspheres",

abstract = "Atorvastatin calcium-loaded polyoxalate (POX) microspheres were prepared by an emulsion solvent-evaporation/extraction method of oil-in-oil-in-water (O1/O2/W) for sustained release. We investigated the release behavior according to initial drug ratio, molecular weight (Mw) and concentration of POX and concentration of emulsifier. The microsphere was characterized on the surface, the cross-section morphology and the behavior of atorvastatin calcium release for 10 days by scanning electron microscopy (SEM) and high performance liquid chromatography (HPLC). The analysis of crystallization was analyzed to use X-ray diffraction (XRD), differential scanning calorimeter (DSC) and Fourier transform infrared (FTIR). These results showed that the release behaviors can be controlled by preparation conditions.",

keywords = "Atorvastatin calcium, Controlled release, Microsphere, O/O/W, Polyoxalate",

author = "Lee, \{Cheon Jung\} and Kim, \{Su Young\} and Lee, \{Hyun Gu\} and Jaewon Yang and Park, \{Jin Young\} and Cha, \{Se Rom\} and Lim, \{Dong Kwon\} and Dongwon Lee and Gilson Khang",

year = "2014",

month = sep,

day = "1",

doi = "10.7317/pk.2014.38.5.656",

language = "English",

volume = "38",

pages = "656--663",

journal = "Polymer (Korea)",

issn = "0379-153X",

number = "5",

}

TY - JOUR

T1 - Preparation and release behavior of atorvastatin calcuim - Encapsulated polyoxalate microspheres

AU - Lee, Cheon Jung

AU - Kim, Su Young

AU - Lee, Hyun Gu

AU - Yang, Jaewon

AU - Park, Jin Young

AU - Cha, Se Rom

AU - Lim, Dong Kwon

AU - Lee, Dongwon

AU - Khang, Gilson

PY - 2014/9/1

Y1 - 2014/9/1

N2 - Atorvastatin calcium-loaded polyoxalate (POX) microspheres were prepared by an emulsion solvent-evaporation/extraction method of oil-in-oil-in-water (O1/O2/W) for sustained release. We investigated the release behavior according to initial drug ratio, molecular weight (Mw) and concentration of POX and concentration of emulsifier. The microsphere was characterized on the surface, the cross-section morphology and the behavior of atorvastatin calcium release for 10 days by scanning electron microscopy (SEM) and high performance liquid chromatography (HPLC). The analysis of crystallization was analyzed to use X-ray diffraction (XRD), differential scanning calorimeter (DSC) and Fourier transform infrared (FTIR). These results showed that the release behaviors can be controlled by preparation conditions.

AB - Atorvastatin calcium-loaded polyoxalate (POX) microspheres were prepared by an emulsion solvent-evaporation/extraction method of oil-in-oil-in-water (O1/O2/W) for sustained release. We investigated the release behavior according to initial drug ratio, molecular weight (Mw) and concentration of POX and concentration of emulsifier. The microsphere was characterized on the surface, the cross-section morphology and the behavior of atorvastatin calcium release for 10 days by scanning electron microscopy (SEM) and high performance liquid chromatography (HPLC). The analysis of crystallization was analyzed to use X-ray diffraction (XRD), differential scanning calorimeter (DSC) and Fourier transform infrared (FTIR). These results showed that the release behaviors can be controlled by preparation conditions.

KW - Atorvastatin calcium

KW - Controlled release

KW - Microsphere

KW - O/O/W

KW - Polyoxalate

UR - https://www.scopus.com/pages/publications/84908136392

U2 - 10.7317/pk.2014.38.5.656

DO - 10.7317/pk.2014.38.5.656

M3 - Journal article

AN - SCOPUS:84908136392

SN - 0379-153X

VL - 38

SP - 656

EP - 663

JO - Polymer (Korea)

JF - Polymer (Korea)

IS - 5

ER -

Preparation and release behavior of atorvastatin calcuim - Encapsulated polyoxalate microspheres

Abstract

Keywords

Quacquarelli Symonds(QS) Subject Topics

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