Abstract
In this work, we prepared nano-emulsified paclitaxel using administration form of the self-microemulsifying drug delivery systems (SMEDDS) in order to increase efficacy of paclitaxel. As paclitaxel delivery carrier, we chose MPEG-PLGA diblock copolymers with different hydrophilic and hydrophobic balances (HLB) by changing PLGA segments under constant MPEG segment. Paclitaxel and MPEG-PLGA diblock copolymers were dissolved by solubilizer such as tetraglycol, Cremophor ELP, and Labrasol. The droplet size for all formulations of nano-emulsified paclitaxel was found in the range of 200-300 nm by dynamic light scattering. The prepared SMEDDS showed a spherical shape of nano-emulsion. The storage stability of the nano-emulsified paclitaxels depended on HLB values of MPEG-PLGA diblock copolymers. In conclusion, we confirmed that the formulations tried in this study could be used as administration form of paclitaxel.
| Original language | English |
|---|---|
| Pages (from-to) | 126-130 |
| Number of pages | 5 |
| Journal | Colloids and Surfaces A: Physicochemical and Engineering Aspects |
| Volume | 313-314 |
| DOIs | |
| State | Published - 2008.02.1 |
Keywords
- MPEG-PLGA diblock copolymers
- Nano-emulsion
- Nano-size
- Paclitaxel
Quacquarelli Symonds(QS) Subject Topics
- Engineering - Petroleum
- Engineering - Chemical
- Chemistry
- Physics & Astronomy
Fingerprint
Dive into the research topics of 'Preparation of nano-emulsified paclitaxel using MPEG-PLGA diblock copolymers'. Together they form a unique fingerprint.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver