Progress of Coordination and Utilization of Zirconium-89 for Positron Emission Tomography (PET) Studies

Minh Thanh La; Van Hieu Tran; Hee Kwon Kim

doi:10.1007/s13139-019-00584-z

Progress of Coordination and Utilization of Zirconium-89 for Positron Emission Tomography (PET) Studies

Minh Thanh La
, Van Hieu Tran
, Hee Kwon Kim^*

^*Corresponding author for this work

Department of Medicine

Jeonbuk National University

Research output: Contribution to journal › Review article › peer-review

23 Scopus citations

Abstract

Radiometals have been commonly used in medical applications, and utilization of such metals continues to be an attractive research area. In particular, a variety of radiometals have been developed and implemented for molecular imaging. For such applications, ⁸⁹Zr has been one of the most interesting radiometals currently used for tumor targeting. Several chemical ligands were developed as ⁸⁹Zr chelators, and new coordinating methods have also been developed more recently. In addition, immuno-positron emission tomography (PET) studies using ⁸⁹Zr-labeled monoclonal antibodies have been performed by several scientists. In this review, recent advances to the coordination of ⁸⁹Zr and the utilization of ⁸⁹Zr in PET studies are described.

Original language	English
Pages (from-to)	115-124
Number of pages	10
Journal	Nuclear Medicine and Molecular Imaging
Volume	53
Issue number	2
DOIs	https://doi.org/10.1007/s13139-019-00584-z
State	Published - 2019.04.1

Keywords

Zr
Coordination
Ligand
Positron emission tomography (PET)

Quacquarelli Symonds(QS) Subject Topics

Medicine

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10.1007/s13139-019-00584-z

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title = "Progress of Coordination and Utilization of Zirconium-89 for Positron Emission Tomography (PET) Studies",

abstract = "Radiometals have been commonly used in medical applications, and utilization of such metals continues to be an attractive research area. In particular, a variety of radiometals have been developed and implemented for molecular imaging. For such applications, 89Zr has been one of the most interesting radiometals currently used for tumor targeting. Several chemical ligands were developed as 89Zr chelators, and new coordinating methods have also been developed more recently. In addition, immuno-positron emission tomography (PET) studies using 89Zr-labeled monoclonal antibodies have been performed by several scientists. In this review, recent advances to the coordination of 89Zr and the utilization of 89Zr in PET studies are described.",

keywords = "Zr, Coordination, Ligand, Positron emission tomography (PET)",

author = "La, \{Minh Thanh\} and Tran, \{Van Hieu\} and Kim, \{Hee Kwon\}",

note = "Publisher Copyright: {\textcopyright} 2019, Korean Society of Nuclear Medicine.",

year = "2019",

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day = "1",

doi = "10.1007/s13139-019-00584-z",

language = "English",

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pages = "115--124",

journal = "Nuclear Medicine and Molecular Imaging",

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T1 - Progress of Coordination and Utilization of Zirconium-89 for Positron Emission Tomography (PET) Studies

AU - La, Minh Thanh

AU - Tran, Van Hieu

AU - Kim, Hee Kwon

PY - 2019/4/1

Y1 - 2019/4/1

N2 - Radiometals have been commonly used in medical applications, and utilization of such metals continues to be an attractive research area. In particular, a variety of radiometals have been developed and implemented for molecular imaging. For such applications, 89Zr has been one of the most interesting radiometals currently used for tumor targeting. Several chemical ligands were developed as 89Zr chelators, and new coordinating methods have also been developed more recently. In addition, immuno-positron emission tomography (PET) studies using 89Zr-labeled monoclonal antibodies have been performed by several scientists. In this review, recent advances to the coordination of 89Zr and the utilization of 89Zr in PET studies are described.

AB - Radiometals have been commonly used in medical applications, and utilization of such metals continues to be an attractive research area. In particular, a variety of radiometals have been developed and implemented for molecular imaging. For such applications, 89Zr has been one of the most interesting radiometals currently used for tumor targeting. Several chemical ligands were developed as 89Zr chelators, and new coordinating methods have also been developed more recently. In addition, immuno-positron emission tomography (PET) studies using 89Zr-labeled monoclonal antibodies have been performed by several scientists. In this review, recent advances to the coordination of 89Zr and the utilization of 89Zr in PET studies are described.

KW - Zr

KW - Coordination

KW - Ligand

KW - Positron emission tomography (PET)

UR - https://www.scopus.com/pages/publications/85064428605

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DO - 10.1007/s13139-019-00584-z

M3 - Review article

AN - SCOPUS:85064428605

SN - 1869-3474

VL - 53

SP - 115

EP - 124

JO - Nuclear Medicine and Molecular Imaging

JF - Nuclear Medicine and Molecular Imaging

IS - 2

ER -

Progress of Coordination and Utilization of Zirconium-89 for Positron Emission Tomography (PET) Studies

Abstract

Keywords

Quacquarelli Symonds(QS) Subject Topics

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