Protection by methanol extract of longan (Dimocarpus Longan Lour.) peel against kainic acid-induced seizure

Young Jun Jo; Jae Soon Eun; Hyoung Chun Kim; Hwang Eui Cho; Mi Kyeong Lee; Bang Yeon Hwang; Jin Tae Hong; Dong Cheul Moon; Ki Wan Oh

Protection by methanol extract of longan (Dimocarpus Longan Lour.) peel against kainic acid-induced seizure

Young Jun Jo
, Jae Soon Eun
, Hyoung Chun Kim
, Hwang Eui Cho
, Mi Kyeong Lee
, Bang Yeon Hwang
, Jin Tae Hong
, Dong Cheul Moon
, Ki Wan Oh^*

^*Corresponding author for this work

Department of Pharmacy

Chungbuk National University
Woosuk University
Kangwon National University

Research output: Contribution to journal › Journal article › peer-review

2 Scopus citations

Abstract

This experiment was undertaken to investigate whether methanol extract of fruit peel of Dimocarpus longan Lour. (MEFL) protects against kainic acid (KA)-induced seizure. Oral administration of MEFL (1, 2 and 4 mg/kg) increased KA (50 mg/kg)-induced survival rate and latency of convulsion onset, and deceased seizure scores and weight loss induced by intraperitoneal (i.p) injection of KA in mice. In addition, MEFL protected against cell death in the hippocampus of rat brain after KA-administration as analyzed by using TUNEL assay in rats. MEFL also significantly blocked seizure-form of electroencephalogram (EEG) power spectra induced by KA in rats. MEFL also inhibited elevation of [Ca²⁺]i and increased [Cl^-]i induced by KA in cultured neuronal cells. Therefore, it is suggested that MEFL protects against seizure induced by KA, decreasing [Ca²⁺]i.

Original language	English
Pages (from-to)	99-106
Number of pages	8
Journal	Natural Product Sciences
Volume	16
Issue number	2
State	Published - 2010.06

Keywords

[Ca ]i
Cell death
Dimocarpus longan
Hippocampus
Kainic acid (KA)
Seizure

Cite this

@article{98e12f6a954e46f4b8f46e0ffea5b4d2,

title = "Protection by methanol extract of longan (Dimocarpus Longan Lour.) peel against kainic acid-induced seizure",

abstract = "This experiment was undertaken to investigate whether methanol extract of fruit peel of Dimocarpus longan Lour. (MEFL) protects against kainic acid (KA)-induced seizure. Oral administration of MEFL (1, 2 and 4 mg/kg) increased KA (50 mg/kg)-induced survival rate and latency of convulsion onset, and deceased seizure scores and weight loss induced by intraperitoneal (i.p) injection of KA in mice. In addition, MEFL protected against cell death in the hippocampus of rat brain after KA-administration as analyzed by using TUNEL assay in rats. MEFL also significantly blocked seizure-form of electroencephalogram (EEG) power spectra induced by KA in rats. MEFL also inhibited elevation of [Ca2+]i and increased [Cl-]i induced by KA in cultured neuronal cells. Therefore, it is suggested that MEFL protects against seizure induced by KA, decreasing [Ca2+]i.",

keywords = "[Ca ]i, Cell death, Dimocarpus longan, Hippocampus, Kainic acid (KA), Seizure",

author = "Jo, \{Young Jun\} and Eun, \{Jae Soon\} and Kim, \{Hyoung Chun\} and Cho, \{Hwang Eui\} and Lee, \{Mi Kyeong\} and Hwang, \{Bang Yeon\} and Hong, \{Jin Tae\} and Moon, \{Dong Cheul\} and Oh, \{Ki Wan\}",

year = "2010",

month = jun,

language = "English",

volume = "16",

pages = "99--106",

journal = "Natural Product Sciences",

issn = "1226-3907",

number = "2",

}

TY - JOUR

T1 - Protection by methanol extract of longan (Dimocarpus Longan Lour.) peel against kainic acid-induced seizure

AU - Jo, Young Jun

AU - Eun, Jae Soon

AU - Kim, Hyoung Chun

AU - Cho, Hwang Eui

AU - Lee, Mi Kyeong

AU - Hwang, Bang Yeon

AU - Hong, Jin Tae

AU - Moon, Dong Cheul

AU - Oh, Ki Wan

PY - 2010/6

Y1 - 2010/6

N2 - This experiment was undertaken to investigate whether methanol extract of fruit peel of Dimocarpus longan Lour. (MEFL) protects against kainic acid (KA)-induced seizure. Oral administration of MEFL (1, 2 and 4 mg/kg) increased KA (50 mg/kg)-induced survival rate and latency of convulsion onset, and deceased seizure scores and weight loss induced by intraperitoneal (i.p) injection of KA in mice. In addition, MEFL protected against cell death in the hippocampus of rat brain after KA-administration as analyzed by using TUNEL assay in rats. MEFL also significantly blocked seizure-form of electroencephalogram (EEG) power spectra induced by KA in rats. MEFL also inhibited elevation of [Ca2+]i and increased [Cl-]i induced by KA in cultured neuronal cells. Therefore, it is suggested that MEFL protects against seizure induced by KA, decreasing [Ca2+]i.

AB - This experiment was undertaken to investigate whether methanol extract of fruit peel of Dimocarpus longan Lour. (MEFL) protects against kainic acid (KA)-induced seizure. Oral administration of MEFL (1, 2 and 4 mg/kg) increased KA (50 mg/kg)-induced survival rate and latency of convulsion onset, and deceased seizure scores and weight loss induced by intraperitoneal (i.p) injection of KA in mice. In addition, MEFL protected against cell death in the hippocampus of rat brain after KA-administration as analyzed by using TUNEL assay in rats. MEFL also significantly blocked seizure-form of electroencephalogram (EEG) power spectra induced by KA in rats. MEFL also inhibited elevation of [Ca2+]i and increased [Cl-]i induced by KA in cultured neuronal cells. Therefore, it is suggested that MEFL protects against seizure induced by KA, decreasing [Ca2+]i.

KW - [Ca ]i

KW - Cell death

KW - Dimocarpus longan

KW - Hippocampus

KW - Kainic acid (KA)

KW - Seizure

UR - https://www.scopus.com/pages/publications/79955005398

M3 - Journal article

AN - SCOPUS:79955005398

SN - 1226-3907

VL - 16

SP - 99

EP - 106

JO - Natural Product Sciences

JF - Natural Product Sciences

IS - 2

ER -

Protection by methanol extract of longan (Dimocarpus Longan Lour.) peel against kainic acid-induced seizure

Abstract

Keywords

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