Protection studies against Marek's disease using baculovirus-expressed glycoproteins B and C of Marek's disease virus type 1

H. K. Jang; T. Kitazawa; M. Ono; Y. Kawaguchi; K. Maeda; N. Yokoyama; Y. Tohya; M. Niikura; T. Mikami

doi:10.1080/03079459608419116

Protection studies against Marek's disease using baculovirus-expressed glycoproteins B and C of Marek's disease virus type 1

H. K. Jang
, T. Kitazawa
, M. Ono
, Y. Kawaguchi
, K. Maeda
, N. Yokoyama
, Y. Tohya
, M. Niikura
, T. Mikami^*

^*Corresponding author for this work

Department of Veterinary Medicine

The University of Tokyo
United States Department of Agriculture

Research output: Contribution to journal › Journal article › peer-review

7 Scopus citations

Abstract

Glycoproteins B (MDV1-gB) and C (MDV1-gC) of Marek's disease virus type 1 (MDV 1) expressed by baculovirus recombinants [rAcNPV(s)] were investigated for their ability to confer protective immunity in chickens against virulent MDV1 challenge. Immunization of chickens with rAcNPV-expressed MDV1-gB induced antibody against MDV1 and resulted in strong protection against the lethal challenge with MDV1. In contrast, immunization of chickens with rAcNPV-expressed MDV1-gC induced antibody against MDV1, but failed to protect against challenge with the virulent MDV1. Co-immunization with both rAcNPV-expressed MDV1-gB and MDV1-gC seemed to show no synergistic effect.

Original language	English
Pages (from-to)	5-24
Number of pages	20
Journal	Avian Pathology
Volume	25
Issue number	1
DOIs	https://doi.org/10.1080/03079459608419116
State	Published - 1996.03

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title = "Protection studies against Marek's disease using baculovirus-expressed glycoproteins B and C of Marek's disease virus type 1",

abstract = "Glycoproteins B (MDV1-gB) and C (MDV1-gC) of Marek's disease virus type 1 (MDV 1) expressed by baculovirus recombinants [rAcNPV(s)] were investigated for their ability to confer protective immunity in chickens against virulent MDV1 challenge. Immunization of chickens with rAcNPV-expressed MDV1-gB induced antibody against MDV1 and resulted in strong protection against the lethal challenge with MDV1. In contrast, immunization of chickens with rAcNPV-expressed MDV1-gC induced antibody against MDV1, but failed to protect against challenge with the virulent MDV1. Co-immunization with both rAcNPV-expressed MDV1-gB and MDV1-gC seemed to show no synergistic effect.",

author = "Jang, \{H. K.\} and T. Kitazawa and M. Ono and Y. Kawaguchi and K. Maeda and N. Yokoyama and Y. Tohya and M. Niikura and T. Mikami",

year = "1996",

month = mar,

doi = "10.1080/03079459608419116",

language = "English",

volume = "25",

pages = "5--24",

journal = "Avian Pathology",

issn = "0307-9457",

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TY - JOUR

T1 - Protection studies against Marek's disease using baculovirus-expressed glycoproteins B and C of Marek's disease virus type 1

AU - Jang, H. K.

AU - Kitazawa, T.

AU - Ono, M.

AU - Kawaguchi, Y.

AU - Maeda, K.

AU - Yokoyama, N.

AU - Tohya, Y.

AU - Niikura, M.

AU - Mikami, T.

PY - 1996/3

Y1 - 1996/3

N2 - Glycoproteins B (MDV1-gB) and C (MDV1-gC) of Marek's disease virus type 1 (MDV 1) expressed by baculovirus recombinants [rAcNPV(s)] were investigated for their ability to confer protective immunity in chickens against virulent MDV1 challenge. Immunization of chickens with rAcNPV-expressed MDV1-gB induced antibody against MDV1 and resulted in strong protection against the lethal challenge with MDV1. In contrast, immunization of chickens with rAcNPV-expressed MDV1-gC induced antibody against MDV1, but failed to protect against challenge with the virulent MDV1. Co-immunization with both rAcNPV-expressed MDV1-gB and MDV1-gC seemed to show no synergistic effect.

AB - Glycoproteins B (MDV1-gB) and C (MDV1-gC) of Marek's disease virus type 1 (MDV 1) expressed by baculovirus recombinants [rAcNPV(s)] were investigated for their ability to confer protective immunity in chickens against virulent MDV1 challenge. Immunization of chickens with rAcNPV-expressed MDV1-gB induced antibody against MDV1 and resulted in strong protection against the lethal challenge with MDV1. In contrast, immunization of chickens with rAcNPV-expressed MDV1-gC induced antibody against MDV1, but failed to protect against challenge with the virulent MDV1. Co-immunization with both rAcNPV-expressed MDV1-gB and MDV1-gC seemed to show no synergistic effect.

UR - https://www.scopus.com/pages/publications/0030055272

U2 - 10.1080/03079459608419116

DO - 10.1080/03079459608419116

M3 - Journal article

AN - SCOPUS:0030055272

SN - 0307-9457

VL - 25

SP - 5

EP - 24

JO - Avian Pathology

JF - Avian Pathology

IS - 1

ER -

Protection studies against Marek's disease using baculovirus-expressed glycoproteins B and C of Marek's disease virus type 1

Abstract

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