Quencher-free molecular beacons as probes for oligonucleotides containing CAG repeat sequences

Ki Tae Kim; Rakesh N. Veedu; Young Jun Seo; Byeang Hyean Kim

doi:10.1039/c3cc48853e

Quencher-free molecular beacons as probes for oligonucleotides containing CAG repeat sequences

Ki Tae Kim
, Rakesh N. Veedu
, Young Jun Seo
, Byeang Hyean Kim^*

^*Corresponding author for this work

Department of Chemistry

Pohang University of Science and Technology
University of Queensland

Research output: Contribution to journal › Journal article › peer-review

18 Scopus citations

Abstract

We have identified quencher-free molecular beacons that allow the sensitive probing of CAG repeat oligonucleotides, including mRNA fragments of trinucleotide repeat diseases, with significant increases in fluorescence intensity mediated by disruption of the stacking of their^PyUunits.

Original language	English
Pages (from-to)	1561-1563
Number of pages	3
Journal	Chemical Communications
Volume	50
Issue number	13
DOIs	https://doi.org/10.1039/c3cc48853e
State	Published - 2014.01.16

Quacquarelli Symonds(QS) Subject Topics

Materials Science
Engineering - Petroleum
Engineering - Chemical
Chemistry

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@article{a7e44bbd15b045ccaeb7b9c81ab5248b,

title = "Quencher-free molecular beacons as probes for oligonucleotides containing CAG repeat sequences",

abstract = "We have identified quencher-free molecular beacons that allow the sensitive probing of CAG repeat oligonucleotides, including mRNA fragments of trinucleotide repeat diseases, with significant increases in fluorescence intensity mediated by disruption of the stacking of theirPyUunits.",

author = "Kim, \{Ki Tae\} and Veedu, \{Rakesh N.\} and Seo, \{Young Jun\} and Kim, \{Byeang Hyean\}",

year = "2014",

month = jan,

day = "16",

doi = "10.1039/c3cc48853e",

language = "English",

volume = "50",

pages = "1561--1563",

journal = "Chemical Communications",

issn = "1359-7345",

number = "13",

}

TY - JOUR

T1 - Quencher-free molecular beacons as probes for oligonucleotides containing CAG repeat sequences

AU - Kim, Ki Tae

AU - Veedu, Rakesh N.

AU - Seo, Young Jun

AU - Kim, Byeang Hyean

PY - 2014/1/16

Y1 - 2014/1/16

N2 - We have identified quencher-free molecular beacons that allow the sensitive probing of CAG repeat oligonucleotides, including mRNA fragments of trinucleotide repeat diseases, with significant increases in fluorescence intensity mediated by disruption of the stacking of theirPyUunits.

AB - We have identified quencher-free molecular beacons that allow the sensitive probing of CAG repeat oligonucleotides, including mRNA fragments of trinucleotide repeat diseases, with significant increases in fluorescence intensity mediated by disruption of the stacking of theirPyUunits.

UR - https://www.scopus.com/pages/publications/84892636001

U2 - 10.1039/c3cc48853e

DO - 10.1039/c3cc48853e

M3 - Journal article

C2 - 24382518

AN - SCOPUS:84892636001

SN - 1359-7345

VL - 50

SP - 1561

EP - 1563

JO - Chemical Communications

JF - Chemical Communications

IS - 13

ER -

Quencher-free molecular beacons as probes for oligonucleotides containing CAG repeat sequences

Abstract

Quacquarelli Symonds(QS) Subject Topics

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