Radioevaluation of PAMs, CMs, and PS-Lip as an oral carrier for vaccine delivery into intestinal Peyer's patches

Chang Moon Lee; Young Jun Heo; Ho Chun Song; Hee Seung Bom; Hyun Chul Lee; Hwan Jeong Jeong; Ki Young Lee

doi:10.1002/ddr.20155

Radioevaluation of PAMs, CMs, and PS-Lip as an oral carrier for vaccine delivery into intestinal Peyer's patches

Chang Moon Lee
, Young Jun Heo
, Ho Chun Song
, Hee Seung Bom
, Hyun Chul Lee
, Hwan Jeong Jeong
, Ki Young Lee^*

^*Corresponding author for this work

Department of Medicine

Jeonbuk National University
Chonnam National University

Research output: Contribution to journal › Journal article › peer-review

4 Scopus citations

Abstract

The aim of the present study was to evaluate the utility of pullulan acetate microparticles (PAMs), chitosan micropaticles (CMs), and dipalmitoylphosphatidyl-serine-liposomes (PS-Lip) as oral carriers for delivery to the intestinal Peyer's patches (PPs). To monitor PP delivery after oral administration, PAMs, CMs, and PS-Lip were radiolabeled with ^99mTc. Radiolabeling efficiencies of the particles were 95 ± 2.5% (PAMs), 87 ± 4.3% (CMs), and 77.2 ± 5.8% (PS-Lip). In delivery studies to the PPs, the percentage of PS-Lip taken up to the PPs was 3.8 × 10 ^-3 ± 0.3% of the administered dose with PS-Lip group showed significantly high uptake compared to the PAM and CM groups. These results suggest that PS-Lip may be used as a potential system for developing an oral delivery carrier.

Original language	English
Pages (from-to)	884-889
Number of pages	6
Journal	Drug Development Research
Volume	67
Issue number	12
DOIs	https://doi.org/10.1002/ddr.20155
State	Published - 2006.12

Keywords

Tc
Liposomes
Microparticles
Oral drug delivery systems
Peyer's patch

Quacquarelli Symonds(QS) Subject Topics

Pharmacy & Pharmacology

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10.1002/ddr.20155

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@article{e0e4a387d9694f65b04786582db4353a,

title = "Radioevaluation of PAMs, CMs, and PS-Lip as an oral carrier for vaccine delivery into intestinal Peyer's patches",

abstract = "The aim of the present study was to evaluate the utility of pullulan acetate microparticles (PAMs), chitosan micropaticles (CMs), and dipalmitoylphosphatidyl-serine-liposomes (PS-Lip) as oral carriers for delivery to the intestinal Peyer's patches (PPs). To monitor PP delivery after oral administration, PAMs, CMs, and PS-Lip were radiolabeled with 99mTc. Radiolabeling efficiencies of the particles were 95 ± 2.5\% (PAMs), 87 ± 4.3\% (CMs), and 77.2 ± 5.8\% (PS-Lip). In delivery studies to the PPs, the percentage of PS-Lip taken up to the PPs was 3.8 × 10 -3 ± 0.3\% of the administered dose with PS-Lip group showed significantly high uptake compared to the PAM and CM groups. These results suggest that PS-Lip may be used as a potential system for developing an oral delivery carrier.",

keywords = "Tc, Liposomes, Microparticles, Oral drug delivery systems, Peyer's patch",

author = "Lee, \{Chang Moon\} and Heo, \{Young Jun\} and Song, \{Ho Chun\} and Bom, \{Hee Seung\} and Lee, \{Hyun Chul\} and Jeong, \{Hwan Jeong\} and Lee, \{Ki Young\}",

year = "2006",

month = dec,

doi = "10.1002/ddr.20155",

language = "English",

volume = "67",

pages = "884--889",

journal = "Drug Development Research",

issn = "0272-4391",

number = "12",

}

TY - JOUR

T1 - Radioevaluation of PAMs, CMs, and PS-Lip as an oral carrier for vaccine delivery into intestinal Peyer's patches

AU - Lee, Chang Moon

AU - Heo, Young Jun

AU - Song, Ho Chun

AU - Bom, Hee Seung

AU - Lee, Hyun Chul

AU - Jeong, Hwan Jeong

AU - Lee, Ki Young

PY - 2006/12

Y1 - 2006/12

N2 - The aim of the present study was to evaluate the utility of pullulan acetate microparticles (PAMs), chitosan micropaticles (CMs), and dipalmitoylphosphatidyl-serine-liposomes (PS-Lip) as oral carriers for delivery to the intestinal Peyer's patches (PPs). To monitor PP delivery after oral administration, PAMs, CMs, and PS-Lip were radiolabeled with 99mTc. Radiolabeling efficiencies of the particles were 95 ± 2.5% (PAMs), 87 ± 4.3% (CMs), and 77.2 ± 5.8% (PS-Lip). In delivery studies to the PPs, the percentage of PS-Lip taken up to the PPs was 3.8 × 10 -3 ± 0.3% of the administered dose with PS-Lip group showed significantly high uptake compared to the PAM and CM groups. These results suggest that PS-Lip may be used as a potential system for developing an oral delivery carrier.

AB - The aim of the present study was to evaluate the utility of pullulan acetate microparticles (PAMs), chitosan micropaticles (CMs), and dipalmitoylphosphatidyl-serine-liposomes (PS-Lip) as oral carriers for delivery to the intestinal Peyer's patches (PPs). To monitor PP delivery after oral administration, PAMs, CMs, and PS-Lip were radiolabeled with 99mTc. Radiolabeling efficiencies of the particles were 95 ± 2.5% (PAMs), 87 ± 4.3% (CMs), and 77.2 ± 5.8% (PS-Lip). In delivery studies to the PPs, the percentage of PS-Lip taken up to the PPs was 3.8 × 10 -3 ± 0.3% of the administered dose with PS-Lip group showed significantly high uptake compared to the PAM and CM groups. These results suggest that PS-Lip may be used as a potential system for developing an oral delivery carrier.

KW - Tc

KW - Liposomes

KW - Microparticles

KW - Oral drug delivery systems

KW - Peyer's patch

UR - https://www.scopus.com/pages/publications/34247206018

U2 - 10.1002/ddr.20155

DO - 10.1002/ddr.20155

M3 - Journal article

AN - SCOPUS:34247206018

SN - 0272-4391

VL - 67

SP - 884

EP - 889

JO - Drug Development Research

JF - Drug Development Research

IS - 12

ER -

Radioevaluation of PAMs, CMs, and PS-Lip as an oral carrier for vaccine delivery into intestinal Peyer's patches

Abstract

Keywords

Quacquarelli Symonds(QS) Subject Topics

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