Radiolytic transformation of rotenone with potential anti-adipogenic activity

Chul Hong Park; Byung Yeoup Chung; Seung Sik Lee; Hyoung Woo Bai; Jae Young Cho; Cheorun Jo; Tae Hoon Kim

doi:10.1016/j.bmcl.2012.12.003

Radiolytic transformation of rotenone with potential anti-adipogenic activity

Chul Hong Park
, Byung Yeoup Chung
, Seung Sik Lee
, Hyoung Woo Bai
, Jae Young Cho
, Cheorun Jo
, Tae Hoon Kim^*

^*Corresponding author for this work

Department of Bioenvironmental Chemistry

Research output: Contribution to journal › Journal article › peer-review

24 Scopus citations

Abstract

Radiolytic transformation of the isoflavonoid rotenone (1) with γ-irradiation afforded two new degraded products, rotenoisins A (2) and (3). The structures of the two new rotenone derivatives were elucidated on the basis of spectroscopic methods. The new products 2 and 3 exhibited significantly enhanced inhibitory activities against pancreatic lipase and adipocyte differentiation in 3T3-L1 cells when compared to parent rotenone.

Original language	English
Pages (from-to)	1099-1103
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	23
Issue number	4
DOIs	https://doi.org/10.1016/j.bmcl.2012.12.003
State	Published - 2013.02.15

Keywords

γ-Irradiation
Adipocyte differentiation
Pancreatic lipase
Radiolytic transformation
Rotenone

Quacquarelli Symonds(QS) Subject Topics

Medicine
Engineering - Petroleum
Pharmacy & Pharmacology
Chemistry
Biological Sciences

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10.1016/j.bmcl.2012.12.003

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@article{70df288582614f1ba579ed042eea919c,

title = "Radiolytic transformation of rotenone with potential anti-adipogenic activity",

abstract = "Radiolytic transformation of the isoflavonoid rotenone (1) with γ-irradiation afforded two new degraded products, rotenoisins A (2) and (3). The structures of the two new rotenone derivatives were elucidated on the basis of spectroscopic methods. The new products 2 and 3 exhibited significantly enhanced inhibitory activities against pancreatic lipase and adipocyte differentiation in 3T3-L1 cells when compared to parent rotenone.",

keywords = "γ-Irradiation, Adipocyte differentiation, Pancreatic lipase, Radiolytic transformation, Rotenone",

author = "Park, \{Chul Hong\} and Chung, \{Byung Yeoup\} and Lee, \{Seung Sik\} and Bai, \{Hyoung Woo\} and Cho, \{Jae Young\} and Cheorun Jo and Kim, \{Tae Hoon\}",

year = "2013",

month = feb,

day = "15",

doi = "10.1016/j.bmcl.2012.12.003",

language = "English",

volume = "23",

pages = "1099--1103",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

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T1 - Radiolytic transformation of rotenone with potential anti-adipogenic activity

AU - Park, Chul Hong

AU - Chung, Byung Yeoup

AU - Lee, Seung Sik

AU - Bai, Hyoung Woo

AU - Cho, Jae Young

AU - Jo, Cheorun

AU - Kim, Tae Hoon

PY - 2013/2/15

Y1 - 2013/2/15

N2 - Radiolytic transformation of the isoflavonoid rotenone (1) with γ-irradiation afforded two new degraded products, rotenoisins A (2) and (3). The structures of the two new rotenone derivatives were elucidated on the basis of spectroscopic methods. The new products 2 and 3 exhibited significantly enhanced inhibitory activities against pancreatic lipase and adipocyte differentiation in 3T3-L1 cells when compared to parent rotenone.

AB - Radiolytic transformation of the isoflavonoid rotenone (1) with γ-irradiation afforded two new degraded products, rotenoisins A (2) and (3). The structures of the two new rotenone derivatives were elucidated on the basis of spectroscopic methods. The new products 2 and 3 exhibited significantly enhanced inhibitory activities against pancreatic lipase and adipocyte differentiation in 3T3-L1 cells when compared to parent rotenone.

KW - γ-Irradiation

KW - Adipocyte differentiation

KW - Pancreatic lipase

KW - Radiolytic transformation

KW - Rotenone

UR - https://www.scopus.com/pages/publications/84872958431

U2 - 10.1016/j.bmcl.2012.12.003

DO - 10.1016/j.bmcl.2012.12.003

M3 - Journal article

C2 - 23317572

AN - SCOPUS:84872958431

SN - 0960-894X

VL - 23

SP - 1099

EP - 1103

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 4

ER -

Radiolytic transformation of rotenone with potential anti-adipogenic activity

Abstract

Keywords

Quacquarelli Symonds(QS) Subject Topics

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