Recent advances in regenerative approaches to intervertebral disc degeneration

Gilson Khang; Jeong Eun Song; Nirmalya Tripathy; Eun Young Kim; Dongwon Lee

doi:10.1007/978-3-319-21813-7_18

Recent advances in regenerative approaches to intervertebral disc degeneration

Gilson Khang^*
, Jeong Eun Song
, Nirmalya Tripathy
, Eun Young Kim
, Dongwon Lee

^*Corresponding author for this work

Department of Polymer -Nano Science &Technology

Jeonbuk National University

Research output: Contribution to conference › Chapter › peer-review

2 Scopus citations

Abstract

Intervertebral disc (IVD) degeneration is one of the major neurodegenerative diseases throughout the world. Development of new and advanced treatment methods are highly warranted due to the limitations of conventional protocols. Very recently, regenerative medicine techniques based on biomaterials, stem cell and bioactive molecules have been demonstrated as the most powerful concept to regenerate IVD. In this chapter, we will review the recent progress in (1) biomaterial scaffolds for annulus fibrosus (AF), nucleus pulposus (NP) and cartilaginous end plates (CEP), (2) stem cells as cell sources, and finally introduce (3) our recent research studies focusing on the fabrication of natural/ synthetic hybrid scaffolds for various purposes during the last 5 years.

Original language	English
Title of host publication	Biomedical Engineering
Subtitle of host publication	Frontier Research and Converging Technologies
Publisher	Springer International Publishing
Pages	427-444
Number of pages	18
Volume	9
ISBN (Electronic)	9783319218137
ISBN (Print)	9783319218120
DOIs	https://doi.org/10.1007/978-3-319-21813-7_18
State	Published - 2015.07.23

Quacquarelli Symonds(QS) Subject Topics

Medicine
Biological Sciences

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10.1007/978-3-319-21813-7_18

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title = "Recent advances in regenerative approaches to intervertebral disc degeneration",

abstract = "Intervertebral disc (IVD) degeneration is one of the major neurodegenerative diseases throughout the world. Development of new and advanced treatment methods are highly warranted due to the limitations of conventional protocols. Very recently, regenerative medicine techniques based on biomaterials, stem cell and bioactive molecules have been demonstrated as the most powerful concept to regenerate IVD. In this chapter, we will review the recent progress in (1) biomaterial scaffolds for annulus fibrosus (AF), nucleus pulposus (NP) and cartilaginous end plates (CEP), (2) stem cells as cell sources, and finally introduce (3) our recent research studies focusing on the fabrication of natural/ synthetic hybrid scaffolds for various purposes during the last 5 years.",

author = "Gilson Khang and Song, \{Jeong Eun\} and Nirmalya Tripathy and Kim, \{Eun Young\} and Dongwon Lee",

note = "Publisher Copyright: {\textcopyright} Springer International Publishing Switzerland 2016. All rights are reserved.",

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doi = "10.1007/978-3-319-21813-7\_18",

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T1 - Recent advances in regenerative approaches to intervertebral disc degeneration

AU - Khang, Gilson

AU - Song, Jeong Eun

AU - Tripathy, Nirmalya

AU - Kim, Eun Young

AU - Lee, Dongwon

PY - 2015/7/23

Y1 - 2015/7/23

N2 - Intervertebral disc (IVD) degeneration is one of the major neurodegenerative diseases throughout the world. Development of new and advanced treatment methods are highly warranted due to the limitations of conventional protocols. Very recently, regenerative medicine techniques based on biomaterials, stem cell and bioactive molecules have been demonstrated as the most powerful concept to regenerate IVD. In this chapter, we will review the recent progress in (1) biomaterial scaffolds for annulus fibrosus (AF), nucleus pulposus (NP) and cartilaginous end plates (CEP), (2) stem cells as cell sources, and finally introduce (3) our recent research studies focusing on the fabrication of natural/ synthetic hybrid scaffolds for various purposes during the last 5 years.

AB - Intervertebral disc (IVD) degeneration is one of the major neurodegenerative diseases throughout the world. Development of new and advanced treatment methods are highly warranted due to the limitations of conventional protocols. Very recently, regenerative medicine techniques based on biomaterials, stem cell and bioactive molecules have been demonstrated as the most powerful concept to regenerate IVD. In this chapter, we will review the recent progress in (1) biomaterial scaffolds for annulus fibrosus (AF), nucleus pulposus (NP) and cartilaginous end plates (CEP), (2) stem cells as cell sources, and finally introduce (3) our recent research studies focusing on the fabrication of natural/ synthetic hybrid scaffolds for various purposes during the last 5 years.

UR - https://www.scopus.com/pages/publications/84956845054

U2 - 10.1007/978-3-319-21813-7_18

DO - 10.1007/978-3-319-21813-7_18

M3 - Chapter

AN - SCOPUS:84956845054

SN - 9783319218120

VL - 9

SP - 427

EP - 444

BT - Biomedical Engineering

PB - Springer International Publishing

ER -

Recent advances in regenerative approaches to intervertebral disc degeneration

Abstract

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