Abstract
RNA interference (RNAi) is being extensively investigated as a potential therapeutic strategy for cancer treatment. However, RNAi-based therapeutics have not yet been used to treat cancer because of their instability and the difficulty of microRNA (miRNA) delivery. Plasmonic nanoparticle-based RNAi nanotherapeutics have been developed for accurate and sensitive diagnosis and a strong therapeutic effect on cancers by leveraging their ease-of-use and specific properties such as photothermal conversion. In this review, recent strategies and advances in plasmonic nanoparticle-based miRNA delivery are briefly presented to facilitate the detection and treatment of several cancers. The challenges and potential opportunities afforded by the RNAi-based theragnosis field are discussed. We expect that the RNAi-integrated plasmonic nanotherapeutics discussed in this review can provide insights for the early diagnosis and effective treatment of cancer.
| Original language | English |
|---|---|
| Pages (from-to) | 228-240 |
| Number of pages | 13 |
| Journal | Journal of Controlled Release |
| Volume | 342 |
| DOIs | |
| State | Published - 2022.02 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- microRNA (miRNA)
- Nanobiosensor
- Photothermal therapy
- Plasmonic nanoparticle
- RNA interference (RNAi)
- Small interference RNA (siRNA)
- Theragnosis
Quacquarelli Symonds(QS) Subject Topics
- Pharmacy & Pharmacology
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