Role of promyelocytic leukemia zinc finger (PLZF) in cell proliferation and cyclin-dependent kinase inhibitor 1A (p21WAF/CDKN1A) Gene repression

Won Il Choi; Min Young Kim; Bu Nam Jeon; Dong In Koh; Chae Ok Yun; Yan Li; Choong Eun Lee; Jiyoung Oh; Kunhong Kim; Man Wook Hur

doi:10.1074/jbc.M113.538751

Role of promyelocytic leukemia zinc finger (PLZF) in cell proliferation and cyclin-dependent kinase inhibitor 1A (p21WAF/CDKN1A) Gene repression

Won Il Choi
, Min Young Kim
, Bu Nam Jeon
, Dong In Koh
, Chae Ok Yun
, Yan Li
, Choong Eun Lee
, Jiyoung Oh
, Kunhong Kim
, Man Wook Hur^*

^*Corresponding author for this work

Department of Medicine

Yonsei University
Hanyang University
Sungkyunkwan University

Research output: Contribution to journal › Journal article › peer-review

43 Scopus citations

Abstract

Background: Promyelocytic leukemia zinc finger (PLZF) is transcription repressor that recruits nuclear co-repressors at the target promoters. PLZF is overexpressed in various human solid tumors, such as clear cell renal carcinoma, glioblastoma, and seminoma. Results: PLZF represses transcription of CDKN1A by inhibition of p53 acetylation, Sp1 binding. Conclusion: PLZF causes cellular transformation and increases cell proliferation by repressing transcription of CDKN1A. Significance: PLZF can act as a proto-oncogene depending on the cell types.

Original language	English
Pages (from-to)	18625-18640
Number of pages	16
Journal	Journal of Biological Chemistry
Volume	289
Issue number	27
DOIs	https://doi.org/10.1074/jbc.M113.538751
State	Published - 2014.07.4

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10.1074/jbc.M113.538751

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@article{bd4defc77b4e4e99ba581fe5419a96e3,

title = "Role of promyelocytic leukemia zinc finger (PLZF) in cell proliferation and cyclin-dependent kinase inhibitor 1A (p21WAF/CDKN1A) Gene repression",

abstract = "Background: Promyelocytic leukemia zinc finger (PLZF) is transcription repressor that recruits nuclear co-repressors at the target promoters. PLZF is overexpressed in various human solid tumors, such as clear cell renal carcinoma, glioblastoma, and seminoma. Results: PLZF represses transcription of CDKN1A by inhibition of p53 acetylation, Sp1 binding. Conclusion: PLZF causes cellular transformation and increases cell proliferation by repressing transcription of CDKN1A. Significance: PLZF can act as a proto-oncogene depending on the cell types.",

author = "Choi, \{Won Il\} and Kim, \{Min Young\} and Jeon, \{Bu Nam\} and Koh, \{Dong In\} and Yun, \{Chae Ok\} and Yan Li and Lee, \{Choong Eun\} and Jiyoung Oh and Kunhong Kim and Hur, \{Man Wook\}",

year = "2014",

month = jul,

day = "4",

doi = "10.1074/jbc.M113.538751",

language = "English",

volume = "289",

pages = "18625--18640",

journal = "Journal of Biological Chemistry",

issn = "0021-9258",

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}

TY - JOUR

T1 - Role of promyelocytic leukemia zinc finger (PLZF) in cell proliferation and cyclin-dependent kinase inhibitor 1A (p21WAF/CDKN1A) Gene repression

AU - Choi, Won Il

AU - Kim, Min Young

AU - Jeon, Bu Nam

AU - Koh, Dong In

AU - Yun, Chae Ok

AU - Li, Yan

AU - Lee, Choong Eun

AU - Oh, Jiyoung

AU - Kim, Kunhong

AU - Hur, Man Wook

PY - 2014/7/4

Y1 - 2014/7/4

N2 - Background: Promyelocytic leukemia zinc finger (PLZF) is transcription repressor that recruits nuclear co-repressors at the target promoters. PLZF is overexpressed in various human solid tumors, such as clear cell renal carcinoma, glioblastoma, and seminoma. Results: PLZF represses transcription of CDKN1A by inhibition of p53 acetylation, Sp1 binding. Conclusion: PLZF causes cellular transformation and increases cell proliferation by repressing transcription of CDKN1A. Significance: PLZF can act as a proto-oncogene depending on the cell types.

AB - Background: Promyelocytic leukemia zinc finger (PLZF) is transcription repressor that recruits nuclear co-repressors at the target promoters. PLZF is overexpressed in various human solid tumors, such as clear cell renal carcinoma, glioblastoma, and seminoma. Results: PLZF represses transcription of CDKN1A by inhibition of p53 acetylation, Sp1 binding. Conclusion: PLZF causes cellular transformation and increases cell proliferation by repressing transcription of CDKN1A. Significance: PLZF can act as a proto-oncogene depending on the cell types.

UR - https://www.scopus.com/pages/publications/84903830168

U2 - 10.1074/jbc.M113.538751

DO - 10.1074/jbc.M113.538751

M3 - Journal article

C2 - 24821727

AN - SCOPUS:84903830168

SN - 0021-9258

VL - 289

SP - 18625

EP - 18640

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 27

ER -

Role of promyelocytic leukemia zinc finger (PLZF) in cell proliferation and cyclin-dependent kinase inhibitor 1A (p21WAF/CDKN1A) Gene repression

Abstract

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