SERS-based flavonoid detection using ethylenediamine-β-cyclodextrin as a capturing ligand

Jae Min Choi; Eunil Hahm; Kyeonghui Park; Daham Jeong; Won Yeop Rho; Jaehi Kim; Dae Hong Jeong; Yoon Sik Lee; Sung Ho Jhang; Hyun Jong Chung; Eunae Cho; Jae Hyuk Yu; Bong Hyun Jun; Seunho Jung

doi:10.3390/nano7010008

SERS-based flavonoid detection using ethylenediamine-β-cyclodextrin as a capturing ligand

Jae Min Choi
, Eunil Hahm
, Kyeonghui Park
, Daham Jeong
, Won Yeop Rho
, Jaehi Kim
, Dae Hong Jeong
, Yoon Sik Lee
, Sung Ho Jhang
, Hyun Jong Chung
, Eunae Cho
, Jae Hyuk Yu
, Bong Hyun Jun^*
, Seunho Jung

^*Corresponding author for this work

Division of International Engineering and Science

Konkuk University
Seoul National University
University of Wisconsin-Madison

Research output: Contribution to journal › Journal article › peer-review

21 Scopus citations

Abstract

Ethylenediamine-modified β-cyclodextrin (Et-β-CD) was immobilized on aggregated silver nanoparticle (NP)-embedded silica NPs (SiO₂@Ag@Et-β-CD NPs) for the effective detection of flavonoids. Silica NPs were used as the template for embedding silver NPs to create hot spots and enhance surface-enhanced Raman scattering (SERS) signals. Et-β-CD was immobilized on Ag NPs to capture flavonoids via host-guest inclusion complex formation, as indicated by enhanced ultraviolet absorption spectra. The resulting SiO₂@Ag@Et-β-CD NPs were used as the SERS substrate for detecting flavonoids, such as hesperetin, naringenin, quercetin, and luteolin. In particular, luteolin was detected more strongly in the linear range 10^-7 to 10^-3 Mthan various organic molecules, namely ethylene glycol, β-estradiol, isopropyl alcohol, naphthalene, and toluene. In addition, the SERS signal for luteolin captured by the SiO₂@Ag@Et-β-CD NPs remained even after repeated washing. These results indicated that the SiO₂@Ag@Et-β-CD NPs can be used as a rapid, sensitive, and selective sensor for flavonoids.

Original language	English
Article number	8
Journal	Nanomaterials
Volume	7
Issue number	1
DOIs	https://doi.org/10.3390/nano7010008
State	Published - 2017.01.1

Keywords

Cyclodextrin
Ethylenediamine cyclodextrin
Flavonoids
Surface-enhanced Raman scattering (SERS)

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10.3390/nano7010008

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@article{3d289a56716b468ebcbd2305dade3156,

title = "SERS-based flavonoid detection using ethylenediamine-β-cyclodextrin as a capturing ligand",

abstract = "Ethylenediamine-modified β-cyclodextrin (Et-β-CD) was immobilized on aggregated silver nanoparticle (NP)-embedded silica NPs (SiO2@Ag@Et-β-CD NPs) for the effective detection of flavonoids. Silica NPs were used as the template for embedding silver NPs to create hot spots and enhance surface-enhanced Raman scattering (SERS) signals. Et-β-CD was immobilized on Ag NPs to capture flavonoids via host-guest inclusion complex formation, as indicated by enhanced ultraviolet absorption spectra. The resulting SiO2@Ag@Et-β-CD NPs were used as the SERS substrate for detecting flavonoids, such as hesperetin, naringenin, quercetin, and luteolin. In particular, luteolin was detected more strongly in the linear range 10-7 to 10-3 Mthan various organic molecules, namely ethylene glycol, β-estradiol, isopropyl alcohol, naphthalene, and toluene. In addition, the SERS signal for luteolin captured by the SiO2@Ag@Et-β-CD NPs remained even after repeated washing. These results indicated that the SiO2@Ag@Et-β-CD NPs can be used as a rapid, sensitive, and selective sensor for flavonoids.",

keywords = "Cyclodextrin, Ethylenediamine cyclodextrin, Flavonoids, Surface-enhanced Raman scattering (SERS)",

author = "Choi, \{Jae Min\} and Eunil Hahm and Kyeonghui Park and Daham Jeong and Rho, \{Won Yeop\} and Jaehi Kim and Jeong, \{Dae Hong\} and Lee, \{Yoon Sik\} and Jhang, \{Sung Ho\} and Chung, \{Hyun Jong\} and Eunae Cho and Yu, \{Jae Hyuk\} and Jun, \{Bong Hyun\} and Seunho Jung",

note = "Publisher Copyright: {\textcopyright} 2017 by the authors; licensee MDPI, Basel, Switzerland.",

year = "2017",

month = jan,

day = "1",

doi = "10.3390/nano7010008",

language = "English",

volume = "7",

journal = "Nanomaterials",

issn = "2079-4991",

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TY - JOUR

T1 - SERS-based flavonoid detection using ethylenediamine-β-cyclodextrin as a capturing ligand

AU - Choi, Jae Min

AU - Hahm, Eunil

AU - Park, Kyeonghui

AU - Jeong, Daham

AU - Rho, Won Yeop

AU - Kim, Jaehi

AU - Jeong, Dae Hong

AU - Lee, Yoon Sik

AU - Jhang, Sung Ho

AU - Chung, Hyun Jong

AU - Cho, Eunae

AU - Yu, Jae Hyuk

AU - Jun, Bong Hyun

AU - Jung, Seunho

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Ethylenediamine-modified β-cyclodextrin (Et-β-CD) was immobilized on aggregated silver nanoparticle (NP)-embedded silica NPs (SiO2@Ag@Et-β-CD NPs) for the effective detection of flavonoids. Silica NPs were used as the template for embedding silver NPs to create hot spots and enhance surface-enhanced Raman scattering (SERS) signals. Et-β-CD was immobilized on Ag NPs to capture flavonoids via host-guest inclusion complex formation, as indicated by enhanced ultraviolet absorption spectra. The resulting SiO2@Ag@Et-β-CD NPs were used as the SERS substrate for detecting flavonoids, such as hesperetin, naringenin, quercetin, and luteolin. In particular, luteolin was detected more strongly in the linear range 10-7 to 10-3 Mthan various organic molecules, namely ethylene glycol, β-estradiol, isopropyl alcohol, naphthalene, and toluene. In addition, the SERS signal for luteolin captured by the SiO2@Ag@Et-β-CD NPs remained even after repeated washing. These results indicated that the SiO2@Ag@Et-β-CD NPs can be used as a rapid, sensitive, and selective sensor for flavonoids.

AB - Ethylenediamine-modified β-cyclodextrin (Et-β-CD) was immobilized on aggregated silver nanoparticle (NP)-embedded silica NPs (SiO2@Ag@Et-β-CD NPs) for the effective detection of flavonoids. Silica NPs were used as the template for embedding silver NPs to create hot spots and enhance surface-enhanced Raman scattering (SERS) signals. Et-β-CD was immobilized on Ag NPs to capture flavonoids via host-guest inclusion complex formation, as indicated by enhanced ultraviolet absorption spectra. The resulting SiO2@Ag@Et-β-CD NPs were used as the SERS substrate for detecting flavonoids, such as hesperetin, naringenin, quercetin, and luteolin. In particular, luteolin was detected more strongly in the linear range 10-7 to 10-3 Mthan various organic molecules, namely ethylene glycol, β-estradiol, isopropyl alcohol, naphthalene, and toluene. In addition, the SERS signal for luteolin captured by the SiO2@Ag@Et-β-CD NPs remained even after repeated washing. These results indicated that the SiO2@Ag@Et-β-CD NPs can be used as a rapid, sensitive, and selective sensor for flavonoids.

KW - Cyclodextrin

KW - Ethylenediamine cyclodextrin

KW - Flavonoids

KW - Surface-enhanced Raman scattering (SERS)

UR - https://www.scopus.com/pages/publications/85009798974

U2 - 10.3390/nano7010008

DO - 10.3390/nano7010008

M3 - Journal article

AN - SCOPUS:85009798974

SN - 2079-4991

VL - 7

JO - Nanomaterials

JF - Nanomaterials

IS - 1

M1 - 8

ER -

SERS-based flavonoid detection using ethylenediamine-β-cyclodextrin as a capturing ligand

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Keywords

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