Sesquiterpenoids from the heartwood of Juniperu s chinensis

Hee Jin Jung; Byung Sun Min; Hyun Ah Jung; Jae Sue Choi

doi:10.20307/nps.2017.23.3.208

Sesquiterpenoids from the heartwood of Juniperu s chinensis

Hee Jin Jung
, Byung Sun Min
, Hyun Ah Jung
, Jae Sue Choi^*

^*Corresponding author for this work

Department of Food Science and Human Nutrition

Pukyong National University
Catholic University of Daegu

Research output: Contribution to journal › Journal article › peer-review

9 Scopus citations

Abstract

A new sesquiterpenoid, 11-hydroxy-valenc-1(10),3(4)-dien-2-one (3), two chemically synthesized but first isolate from nature, 3-oxocedran-8β-ol (1) and valenc-1(10),3(4),11(12)-trien-2-one (2) along with four known compounds, sugiol (4), (+)-nootkatone (5), 11-hydroxy-valenc-1(10)-en-2-one (6), and clovandiol (7), were isolated from the heartwood of Juniperus chinensis. All chemical structures were elucidated using extensive spectroscopic analysis including 1D and 2D NMR spectroscopy. Valenc-1(10),3(4),11(12)-trien-2-one (2) exhibited significant inhibitory activity against butyrylcholinesterase with an IC₅₀ value of 68.45 μM.

Original language	English
Pages (from-to)	208-212
Number of pages	5
Journal	Natural Product Sciences
Volume	23
Issue number	3
DOIs	https://doi.org/10.20307/nps.2017.23.3.208
State	Published - 2017

Keywords

11-Hydroxy-valenc- 1(10),3(4)-dien-2-one
3-Oxocedran-8β-ol
Acetylcholinesterase
Butyrylcholinesterase
Juniperus chinensis
Valenc-1(10),3(4),11(12)-trien-2-one

Quacquarelli Symonds(QS) Subject Topics

Engineering - Petroleum
Pharmacy & Pharmacology
Chemistry

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10.20307/nps.2017.23.3.208

Cite this

@article{31fe717116b14997af534b0970dd23b1,

title = "Sesquiterpenoids from the heartwood of Juniperu s chinensis",

abstract = "A new sesquiterpenoid, 11-hydroxy-valenc-1(10),3(4)-dien-2-one (3), two chemically synthesized but first isolate from nature, 3-oxocedran-8β-ol (1) and valenc-1(10),3(4),11(12)-trien-2-one (2) along with four known compounds, sugiol (4), (+)-nootkatone (5), 11-hydroxy-valenc-1(10)-en-2-one (6), and clovandiol (7), were isolated from the heartwood of Juniperus chinensis. All chemical structures were elucidated using extensive spectroscopic analysis including 1D and 2D NMR spectroscopy. Valenc-1(10),3(4),11(12)-trien-2-one (2) exhibited significant inhibitory activity against butyrylcholinesterase with an IC50 value of 68.45 μM.",

keywords = "11-Hydroxy-valenc- 1(10),3(4)-dien-2-one, 3-Oxocedran-8β-ol, Acetylcholinesterase, Butyrylcholinesterase, Juniperus chinensis, Valenc-1(10),3(4),11(12)-trien-2-one",

author = "Jung, \{Hee Jin\} and Min, \{Byung Sun\} and Jung, \{Hyun Ah\} and Choi, \{Jae Sue\}",

year = "2017",

doi = "10.20307/nps.2017.23.3.208",

language = "English",

volume = "23",

pages = "208--212",

journal = "Natural Product Sciences",

issn = "1226-3907",

number = "3",

}

TY - JOUR

T1 - Sesquiterpenoids from the heartwood of Juniperu s chinensis

AU - Jung, Hee Jin

AU - Min, Byung Sun

AU - Jung, Hyun Ah

AU - Choi, Jae Sue

PY - 2017

Y1 - 2017

N2 - A new sesquiterpenoid, 11-hydroxy-valenc-1(10),3(4)-dien-2-one (3), two chemically synthesized but first isolate from nature, 3-oxocedran-8β-ol (1) and valenc-1(10),3(4),11(12)-trien-2-one (2) along with four known compounds, sugiol (4), (+)-nootkatone (5), 11-hydroxy-valenc-1(10)-en-2-one (6), and clovandiol (7), were isolated from the heartwood of Juniperus chinensis. All chemical structures were elucidated using extensive spectroscopic analysis including 1D and 2D NMR spectroscopy. Valenc-1(10),3(4),11(12)-trien-2-one (2) exhibited significant inhibitory activity against butyrylcholinesterase with an IC50 value of 68.45 μM.

AB - A new sesquiterpenoid, 11-hydroxy-valenc-1(10),3(4)-dien-2-one (3), two chemically synthesized but first isolate from nature, 3-oxocedran-8β-ol (1) and valenc-1(10),3(4),11(12)-trien-2-one (2) along with four known compounds, sugiol (4), (+)-nootkatone (5), 11-hydroxy-valenc-1(10)-en-2-one (6), and clovandiol (7), were isolated from the heartwood of Juniperus chinensis. All chemical structures were elucidated using extensive spectroscopic analysis including 1D and 2D NMR spectroscopy. Valenc-1(10),3(4),11(12)-trien-2-one (2) exhibited significant inhibitory activity against butyrylcholinesterase with an IC50 value of 68.45 μM.

KW - 11-Hydroxy-valenc- 1(10),3(4)-dien-2-one

KW - 3-Oxocedran-8β-ol

KW - Acetylcholinesterase

KW - Butyrylcholinesterase

KW - Juniperus chinensis

KW - Valenc-1(10),3(4),11(12)-trien-2-one

UR - https://www.scopus.com/pages/publications/85032750682

U2 - 10.20307/nps.2017.23.3.208

DO - 10.20307/nps.2017.23.3.208

M3 - Journal article

AN - SCOPUS:85032750682

SN - 1226-3907

VL - 23

SP - 208

EP - 212

JO - Natural Product Sciences

JF - Natural Product Sciences

IS - 3

ER -

Sesquiterpenoids from the heartwood of Juniperu s chinensis

Abstract

Keywords

Quacquarelli Symonds(QS) Subject Topics

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