Surface-engineered platelet activation for implantable applications of parylene-coated polydimethylsiloxane

This study analyzed the characteristics of platelet attachment and activation depending on different condition of surfaces (PDMS and parylene on PDMS) for implantable biomaterials. The attached platelets were observed more on the PDMS substrate with the softer surface property, as compared to the parylene-on-the-PDMS substrate. However, due to the effect of the roughness of substrates, the platelets were rapidly activated on the parylene-on-PDMS substrate. Therefore, both softness and roughness of implantable biomaterials need to be regarded as important parameters in surface-engineered platelet applications.