Abstract
Abstract: A novel series of dihydropyranoaurone derivatives were synthesized and evaluated as potential anti-inflammatory agents. Late-stage derivatization by versatile piperazine-catalyzed aldol reaction between dihydropyanobenzofuran intermediate 2 and diverse aldehydes readily afforded the novel dihydropyranoaurone analogs. Evaluation of the synthesized dihydropyranoaurone derivatives and related compounds regarding their inhibiting inducible nitric oxide synthase and nitrite production of lipopolysaccaride-stimulated RAW 264.7 cells provided insight into the structure–activity relationship of aurone derivatives.
| Original language | English |
|---|---|
| Pages (from-to) | 695-703 |
| Number of pages | 9 |
| Journal | Archives of Pharmacal Research |
| Volume | 40 |
| Issue number | 6 |
| DOIs | |
| State | Published - 2017.06.1 |
Keywords
- Aldol reaction
- Anti-inflammation
- Dihydropyranoaurone
- Late-stage derivatization
- Nitric oxide
- Synthesis
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