Abstract
p-Carboxyphenoxy propane (CPP) prepolymer consisting of 4 units and sebacic acid (SA) prepolymer consisting of about 10 units were synthesized by reacting CPP and SA in the presence of excess acetic anhydride, respectively. Polyanhydride, poly(CPP-SA) copolymers were copolymerized by a melt polycondensation process with a mixture of CPP and SA prepolymer. Copolymers of average molecular weight up to 110,000 g/mol were achieved. The crystallinity of poly(CPP-SA) copolymers was decreased by the addition of the CPP homopolymer segment to SA homopolymer. Poly(CPP-SA) copolymers gradually degraded for period of 10 days. No large difference of weight loss observed according to molecular weight variation of poly(CPP-SA) copolymers. BCNU release from wafers fabricated by poly(CPP-SA) showed a sustained release pattern with no initial burst and delay of drug release.
| Original language | English |
|---|---|
| Pages (from-to) | 229-238 |
| Number of pages | 10 |
| Journal | Bio-Medical Materials and Engineering |
| Volume | 15 |
| Issue number | 3 |
| State | Published - 2005 |
Keywords
- BCNU
- Polyanhydride
- Polycondensation
- Sustained drug release
Quacquarelli Symonds(QS) Subject Topics
- Materials Science
- Biological Sciences
Fingerprint
Dive into the research topics of 'Synthesis and characterization of polyanhydride for local BCNU delivery carriers'. Together they form a unique fingerprint.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver