Synthesis and evaluation of the lifespan-extension properties of oleracones D-F, antioxidative flavonoids from Portulaca oleracea L.

Jeong A. Yoon; Changjin Lim; Dong Seok Cha; Young Taek Han

doi:10.3390/app9194014

Synthesis and evaluation of the lifespan-extension properties of oleracones D-F, antioxidative flavonoids from Portulaca oleracea L.

Jeong A. Yoon
, Changjin Lim
, Dong Seok Cha^*
, Young Taek Han

^*Corresponding author for this work

Department of Pharmacy

Dankook University
CHA University
Woosuk University

Research output: Contribution to journal › Journal article › peer-review

8 Scopus citations

Abstract

Plant-derived antioxidants have been widely used as supplementary health foods, as well as having been regarded as drug candidates for aging and aging-associated diseases. Oleracones, a novel series of flavonoids isolated from Portulaca oleracea L., possess potent antioxidative activities and are expected to exhibit therapeutic potential on the aging process. The current paper describes the concise sequential synthesis of oleracones D-F. Oleracones D and F were efficiently synthesized via selective intramolecular oxa-Michael addition from oleracone E. In addition, we investigated their possible lifespan-extension properties using Caenorhabditis elegans, which is excellently suited as an experimental model to study aging. A significant longevity effect was observed when nematodes were grown with 20 μM of oleracone E.

Original language	English
Article number	4014
Journal	Applied Sciences (Switzerland)
Volume	9
Issue number	19
DOIs	https://doi.org/10.3390/app9194014
State	Published - 2019.10.1

Keywords

Anti-aging
Caenorhabditis elegans
Flavonoid
Longevity
Oleracone
Portulaca oleracea L.
Total synthesis

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10.3390/app9194014

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title = "Synthesis and evaluation of the lifespan-extension properties of oleracones D-F, antioxidative flavonoids from Portulaca oleracea L.",

abstract = "Plant-derived antioxidants have been widely used as supplementary health foods, as well as having been regarded as drug candidates for aging and aging-associated diseases. Oleracones, a novel series of flavonoids isolated from Portulaca oleracea L., possess potent antioxidative activities and are expected to exhibit therapeutic potential on the aging process. The current paper describes the concise sequential synthesis of oleracones D-F. Oleracones D and F were efficiently synthesized via selective intramolecular oxa-Michael addition from oleracone E. In addition, we investigated their possible lifespan-extension properties using Caenorhabditis elegans, which is excellently suited as an experimental model to study aging. A significant longevity effect was observed when nematodes were grown with 20 μM of oleracone E.",

keywords = "Anti-aging, Caenorhabditis elegans, Flavonoid, Longevity, Oleracone, Portulaca oleracea L., Total synthesis",

author = "Yoon, \{Jeong A.\} and Changjin Lim and Cha, \{Dong Seok\} and Han, \{Young Taek\}",

note = "Publisher Copyright: {\textcopyright} 2019 by the authors.",

year = "2019",

month = oct,

day = "1",

doi = "10.3390/app9194014",

language = "English",

volume = "9",

journal = "Applied Sciences (Switzerland)",

issn = "2076-3417",

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TY - JOUR

T1 - Synthesis and evaluation of the lifespan-extension properties of oleracones D-F, antioxidative flavonoids from Portulaca oleracea L.

AU - Yoon, Jeong A.

AU - Lim, Changjin

AU - Cha, Dong Seok

AU - Han, Young Taek

PY - 2019/10/1

Y1 - 2019/10/1

N2 - Plant-derived antioxidants have been widely used as supplementary health foods, as well as having been regarded as drug candidates for aging and aging-associated diseases. Oleracones, a novel series of flavonoids isolated from Portulaca oleracea L., possess potent antioxidative activities and are expected to exhibit therapeutic potential on the aging process. The current paper describes the concise sequential synthesis of oleracones D-F. Oleracones D and F were efficiently synthesized via selective intramolecular oxa-Michael addition from oleracone E. In addition, we investigated their possible lifespan-extension properties using Caenorhabditis elegans, which is excellently suited as an experimental model to study aging. A significant longevity effect was observed when nematodes were grown with 20 μM of oleracone E.

AB - Plant-derived antioxidants have been widely used as supplementary health foods, as well as having been regarded as drug candidates for aging and aging-associated diseases. Oleracones, a novel series of flavonoids isolated from Portulaca oleracea L., possess potent antioxidative activities and are expected to exhibit therapeutic potential on the aging process. The current paper describes the concise sequential synthesis of oleracones D-F. Oleracones D and F were efficiently synthesized via selective intramolecular oxa-Michael addition from oleracone E. In addition, we investigated their possible lifespan-extension properties using Caenorhabditis elegans, which is excellently suited as an experimental model to study aging. A significant longevity effect was observed when nematodes were grown with 20 μM of oleracone E.

KW - Anti-aging

KW - Caenorhabditis elegans

KW - Flavonoid

KW - Longevity

KW - Oleracone

KW - Portulaca oleracea L.

KW - Total synthesis

UR - https://www.scopus.com/pages/publications/85073298086

U2 - 10.3390/app9194014

DO - 10.3390/app9194014

M3 - Journal article

AN - SCOPUS:85073298086

SN - 2076-3417

VL - 9

JO - Applied Sciences (Switzerland)

JF - Applied Sciences (Switzerland)

IS - 19

M1 - 4014

ER -

Synthesis and evaluation of the lifespan-extension properties of oleracones D-F, antioxidative flavonoids from Portulaca oleracea L.

Abstract

Keywords

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