Synthesis of 1,2-amino alcohols via catalytic C-H amidation of sp3 methyl C-H bonds

Taek Kang; Heejeong Kim; Jeung Gon Kim; Sukbok Chang

doi:10.1039/c4cc05655h

Synthesis of 1,2-amino alcohols via catalytic C-H amidation of sp³ methyl C-H bonds

Taek Kang
, Heejeong Kim
, Jeung Gon Kim^*
, Sukbok Chang

^*Corresponding author for this work

Department of Chemistry

Institute for Basic Science
Korea Advanced Institute of Science and Technology

Research output: Contribution to journal › Journal article › peer-review

85 Scopus citations

Abstract

Herein a new synthetic route to 1,2-amino alcohols is presented by using C-H amidation of sp³ methyl C-H bonds as a key step. Readily available alcohols were employed as starting materials after converting them to removable ketoxime chelating groups. Iridium catalysts were found to be effective for the C-H amidation, and LAH reduction was then used to furnish β-amino alcohol products.

Original language	English
Pages (from-to)	12073-12075
Number of pages	3
Journal	Chemical Communications
Volume	50
Issue number	81
DOIs	https://doi.org/10.1039/c4cc05655h
State	Published - 2014.09.16

Access to Document

10.1039/c4cc05655h

Cite this

@article{52de41de71144340a6bc509b9b434b57,

title = "Synthesis of 1,2-amino alcohols via catalytic C-H amidation of sp3 methyl C-H bonds",

abstract = "Herein a new synthetic route to 1,2-amino alcohols is presented by using C-H amidation of sp3 methyl C-H bonds as a key step. Readily available alcohols were employed as starting materials after converting them to removable ketoxime chelating groups. Iridium catalysts were found to be effective for the C-H amidation, and LAH reduction was then used to furnish β-amino alcohol products.",

author = "Taek Kang and Heejeong Kim and Kim, \{Jeung Gon\} and Sukbok Chang",

year = "2014",

month = sep,

day = "16",

doi = "10.1039/c4cc05655h",

language = "English",

volume = "50",

pages = "12073--12075",

journal = "Chemical Communications",

issn = "1359-7345",

number = "81",

}

TY - JOUR

T1 - Synthesis of 1,2-amino alcohols via catalytic C-H amidation of sp3 methyl C-H bonds

AU - Kang, Taek

AU - Kim, Heejeong

AU - Kim, Jeung Gon

AU - Chang, Sukbok

PY - 2014/9/16

Y1 - 2014/9/16

N2 - Herein a new synthetic route to 1,2-amino alcohols is presented by using C-H amidation of sp3 methyl C-H bonds as a key step. Readily available alcohols were employed as starting materials after converting them to removable ketoxime chelating groups. Iridium catalysts were found to be effective for the C-H amidation, and LAH reduction was then used to furnish β-amino alcohol products.

AB - Herein a new synthetic route to 1,2-amino alcohols is presented by using C-H amidation of sp3 methyl C-H bonds as a key step. Readily available alcohols were employed as starting materials after converting them to removable ketoxime chelating groups. Iridium catalysts were found to be effective for the C-H amidation, and LAH reduction was then used to furnish β-amino alcohol products.

UR - https://www.scopus.com/pages/publications/84907860063

U2 - 10.1039/c4cc05655h

DO - 10.1039/c4cc05655h

M3 - Journal article

C2 - 25164364

AN - SCOPUS:84907860063

SN - 1359-7345

VL - 50

SP - 12073

EP - 12075

JO - Chemical Communications

JF - Chemical Communications

IS - 81

ER -

Synthesis of 1,2-amino alcohols via catalytic C-H amidation of sp³ methyl C-H bonds

Abstract

Access to Document

Other files and links

Fingerprint

Cite this