Synthesis of C17-OH-north unit of ritterazine G via "red-Ox" modifications of hecogenin acetate

Young Cheun; Yi Kou; Begoña Stevenson; Hee Kwon Kim; Myong Chul Koag; Seongmin Lee

doi:10.1016/j.steroids.2013.02.015

Synthesis of C17-OH-north unit of ritterazine G via "red-Ox" modifications of hecogenin acetate

Young Cheun
, Yi Kou
, Begoña Stevenson
, Hee Kwon Kim
, Myong Chul Koag
, Seongmin Lee^*

^*Corresponding author for this work

Department of Medicine

University of Texas at Austin

Research output: Contribution to journal › Journal article › peer-review

8 Scopus citations

Abstract

The C17-OH-north unit of ritterazine G was prepared in 13 steps from hecogenin acetate. This synthesis features a highly efficient and stereoselective introduction of the C17-OH via E-ring cleavage/F-ring formation, D-ring oxidation, and F-ring cleavage/E-ring formation.

Original language	English
Pages (from-to)	639-643
Number of pages	5
Journal	Steroids
Volume	78
Issue number	7
DOIs	https://doi.org/10.1016/j.steroids.2013.02.015
State	Published - 2013.07

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Anticancer steroids
Cephalostatin
Ritterazine
Steroidal alkaloid

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10.1016/j.steroids.2013.02.015

Cite this

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title = "Synthesis of C17-OH-north unit of ritterazine G via {"}red-Ox{"} modifications of hecogenin acetate",

abstract = "The C17-OH-north unit of ritterazine G was prepared in 13 steps from hecogenin acetate. This synthesis features a highly efficient and stereoselective introduction of the C17-OH via E-ring cleavage/F-ring formation, D-ring oxidation, and F-ring cleavage/E-ring formation.",

keywords = "Anticancer steroids, Cephalostatin, Ritterazine, Steroidal alkaloid",

author = "Young Cheun and Yi Kou and Bego{\~n}a Stevenson and Kim, \{Hee Kwon\} and Koag, \{Myong Chul\} and Seongmin Lee",

year = "2013",

month = jul,

doi = "10.1016/j.steroids.2013.02.015",

language = "English",

volume = "78",

pages = "639--643",

journal = "Steroids",

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T1 - Synthesis of C17-OH-north unit of ritterazine G via "red-Ox" modifications of hecogenin acetate

AU - Cheun, Young

AU - Kou, Yi

AU - Stevenson, Begoña

AU - Kim, Hee Kwon

AU - Koag, Myong Chul

AU - Lee, Seongmin

PY - 2013/7

Y1 - 2013/7

N2 - The C17-OH-north unit of ritterazine G was prepared in 13 steps from hecogenin acetate. This synthesis features a highly efficient and stereoselective introduction of the C17-OH via E-ring cleavage/F-ring formation, D-ring oxidation, and F-ring cleavage/E-ring formation.

AB - The C17-OH-north unit of ritterazine G was prepared in 13 steps from hecogenin acetate. This synthesis features a highly efficient and stereoselective introduction of the C17-OH via E-ring cleavage/F-ring formation, D-ring oxidation, and F-ring cleavage/E-ring formation.

KW - Anticancer steroids

KW - Cephalostatin

KW - Ritterazine

KW - Steroidal alkaloid

UR - https://www.scopus.com/pages/publications/84877018927

U2 - 10.1016/j.steroids.2013.02.015

DO - 10.1016/j.steroids.2013.02.015

M3 - Journal article

C2 - 23500411

AN - SCOPUS:84877018927

SN - 0039-128X

VL - 78

SP - 639

EP - 643

JO - Steroids

JF - Steroids

IS - 7

ER -

Synthesis of C17-OH-north unit of ritterazine G via "red-Ox" modifications of hecogenin acetate

Abstract

UN SDGs

Keywords

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