Synthesis of diverse tracers on ewod microdevice for positron emission tomography (PET)

S. Chen; R. Javed; J. Lei; H. K. Kim; G. Flores; R. M. Van Dam; P. Y. Keng; C. J. Kim

doi:10.31438/trf.hh2012.50

Synthesis of diverse tracers on ewod microdevice for positron emission tomography (PET)

S. Chen^*
, R. Javed
, J. Lei
, H. K. Kim
, G. Flores
, R. M. Van Dam
, P. Y. Keng
, C. J. Kim

^*Corresponding author for this work

Department of Medicine

University of California at Los Angeles

Research output: Contribution to conference › Conference paper › peer-review

6 Scopus citations

Abstract

We demonstrate the synthesis of diverse tracers (sugar, DNA nucleoside, protein labeling compound, and neurotransmitter) using a single electrowetting-on-dielectric (EWOD) chip design with multifunctional electrodes for heating, temperature sensing, and EWOD driving. Furthermore, we present a key advantage of microfluidic chemical synthesis in increasing specific activity (radioactivity per mass of tracer) compared to macroscale synthesis. These are important steps toward more affordable, specific, and universal tracer production for use in positron emission tomography (PET).

Original language	English
Title of host publication	2012 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2012
Editors	Mehran Mehregany, David J. Monk
Publisher	Transducer Research Foundation
Pages	189-192
Number of pages	4
ISBN (Electronic)	9780964002494
DOIs	https://doi.org/10.31438/trf.hh2012.50
State	Published - 2012
Event	2012 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2012 - Hilton Head, United States Duration: 2012.06.3 → 2012.06.7

Publication series

Name	Technical Digest - Solid-State Sensors, Actuators, and Microsystems Workshop

Conference

Conference	2012 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2012
Country/Territory	United States
City	Hilton Head
Period	12.06.3 → 12.06.7

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10.31438/trf.hh2012.50

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Chen, S., Javed, R., Lei, J., Kim, H. K., Flores, G., Van Dam, R. M., Keng, P. Y., & Kim, C. J. (2012). Synthesis of diverse tracers on ewod microdevice for positron emission tomography (PET). In M. Mehregany, & D. J. Monk (Eds.), 2012 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2012 (pp. 189-192). (Technical Digest - Solid-State Sensors, Actuators, and Microsystems Workshop). Transducer Research Foundation. https://doi.org/10.31438/trf.hh2012.50

Chen, S. ; Javed, R. ; Lei, J. et al. / Synthesis of diverse tracers on ewod microdevice for positron emission tomography (PET). 2012 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2012. editor / Mehran Mehregany ; David J. Monk. Transducer Research Foundation, 2012. pp. 189-192 (Technical Digest - Solid-State Sensors, Actuators, and Microsystems Workshop).

@inproceedings{9d7a03dcbebb4fdc9c9f50c8ba13be6f,

title = "Synthesis of diverse tracers on ewod microdevice for positron emission tomography (PET)",

abstract = "We demonstrate the synthesis of diverse tracers (sugar, DNA nucleoside, protein labeling compound, and neurotransmitter) using a single electrowetting-on-dielectric (EWOD) chip design with multifunctional electrodes for heating, temperature sensing, and EWOD driving. Furthermore, we present a key advantage of microfluidic chemical synthesis in increasing specific activity (radioactivity per mass of tracer) compared to macroscale synthesis. These are important steps toward more affordable, specific, and universal tracer production for use in positron emission tomography (PET).",

author = "S. Chen and R. Javed and J. Lei and Kim, \{H. K.\} and G. Flores and \{Van Dam\}, \{R. M.\} and Keng, \{P. Y.\} and Kim, \{C. J.\}",

note = "Publisher Copyright: {\textcopyright} 2012 TRF.; 2012 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2012 ; Conference date: 03-06-2012 Through 07-06-2012",

year = "2012",

doi = "10.31438/trf.hh2012.50",

language = "English",

series = "Technical Digest - Solid-State Sensors, Actuators, and Microsystems Workshop",

publisher = "Transducer Research Foundation",

pages = "189--192",

editor = "Mehran Mehregany and Monk, \{David J.\}",

booktitle = "2012 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2012",

}

Chen, S, Javed, R, Lei, J, Kim, HK, Flores, G, Van Dam, RM, Keng, PY & Kim, CJ 2012, Synthesis of diverse tracers on ewod microdevice for positron emission tomography (PET). in M Mehregany & DJ Monk (eds), 2012 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2012. Technical Digest - Solid-State Sensors, Actuators, and Microsystems Workshop, Transducer Research Foundation, pp. 189-192, 2012 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2012, Hilton Head, United States, 12.06.3. https://doi.org/10.31438/trf.hh2012.50

Synthesis of diverse tracers on ewod microdevice for positron emission tomography (PET). / Chen, S.; Javed, R.; Lei, J. et al.
2012 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2012. ed. / Mehran Mehregany; David J. Monk. Transducer Research Foundation, 2012. p. 189-192 (Technical Digest - Solid-State Sensors, Actuators, and Microsystems Workshop).

Research output: Contribution to conference › Conference paper › peer-review

TY - GEN

T1 - Synthesis of diverse tracers on ewod microdevice for positron emission tomography (PET)

AU - Chen, S.

AU - Javed, R.

AU - Lei, J.

AU - Kim, H. K.

AU - Flores, G.

AU - Van Dam, R. M.

AU - Keng, P. Y.

AU - Kim, C. J.

PY - 2012

Y1 - 2012

N2 - We demonstrate the synthesis of diverse tracers (sugar, DNA nucleoside, protein labeling compound, and neurotransmitter) using a single electrowetting-on-dielectric (EWOD) chip design with multifunctional electrodes for heating, temperature sensing, and EWOD driving. Furthermore, we present a key advantage of microfluidic chemical synthesis in increasing specific activity (radioactivity per mass of tracer) compared to macroscale synthesis. These are important steps toward more affordable, specific, and universal tracer production for use in positron emission tomography (PET).

AB - We demonstrate the synthesis of diverse tracers (sugar, DNA nucleoside, protein labeling compound, and neurotransmitter) using a single electrowetting-on-dielectric (EWOD) chip design with multifunctional electrodes for heating, temperature sensing, and EWOD driving. Furthermore, we present a key advantage of microfluidic chemical synthesis in increasing specific activity (radioactivity per mass of tracer) compared to macroscale synthesis. These are important steps toward more affordable, specific, and universal tracer production for use in positron emission tomography (PET).

UR - https://www.scopus.com/pages/publications/84880806655

U2 - 10.31438/trf.hh2012.50

DO - 10.31438/trf.hh2012.50

M3 - Conference paper

AN - SCOPUS:84880806655

T3 - Technical Digest - Solid-State Sensors, Actuators, and Microsystems Workshop

SP - 189

EP - 192

BT - 2012 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2012

A2 - Mehregany, Mehran

A2 - Monk, David J.

PB - Transducer Research Foundation

T2 - 2012 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2012

Y2 - 3 June 2012 through 7 June 2012

ER -

Chen S, Javed R, Lei J, Kim HK, Flores G, Van Dam RM et al. Synthesis of diverse tracers on ewod microdevice for positron emission tomography (PET). In Mehregany M, Monk DJ, editors, 2012 Solid-State Sensors, Actuators and Microsystems Workshop, Hilton Head 2012. Transducer Research Foundation. 2012. p. 189-192. (Technical Digest - Solid-State Sensors, Actuators, and Microsystems Workshop). doi: 10.31438/trf.hh2012.50

Synthesis of diverse tracers on ewod microdevice for positron emission tomography (PET)

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