Synthesis of high porous electrospun hollow TiO2 nanofibers for bone tissue engineering application

Surya Prasad Adhikari; Hem Raj Pant; Hamouda M. Mousa; Joshua Lee; Han Joo Kim; Chan Hee Park; Cheol Sang Kim

doi:10.1016/j.jiec.2015.12.004

Synthesis of high porous electrospun hollow TiO₂ nanofibers for bone tissue engineering application

Surya Prasad Adhikari
, Hem Raj Pant
, Hamouda M. Mousa
, Joshua Lee
, Han Joo Kim
, Chan Hee Park^*
, Cheol Sang Kim

^*Corresponding author for this work

Nano-Bio Mechanical System Engineering

Research output: Contribution to journal › Journal article › peer-review

39 Scopus citations

Abstract

Highly porous, hollow TiO₂ nanofibers (NFs) were fabricated through coaxial nozzle electrospinning using a polymer sol-gel solution of CaCO₃ and TiO₂ precursor. Hollow and porous TiO₂ NFs were obtained by etching CaCO₃ on calcined TiO₂ fibers using dilute HCl. Characterization of the as-synthesized materials were performed using FE-SEM and XRD before and after 24 h of bio-mineralization. The in vitro cell culture test was performed using MC3T3-E1 osteoblast cells to assess cell response of the different NFs. The results suggested that as-synthesized porous nanotubes have better biocompatibility for bone regeneration and implantations compared to other nonporous TiO₂ nanorods or NFs.

Original language	English
Pages (from-to)	75-82
Number of pages	8
Journal	Journal of Industrial and Engineering Chemistry
Volume	35
DOIs	https://doi.org/10.1016/j.jiec.2015.12.004
State	Published - 2016.03.25

Keywords

Biomaterials
Bone tissue engineering
Coaxial electrospinning
Nanotubes
TiO

Quacquarelli Symonds(QS) Subject Topics

Engineering - Chemical

Access to Document

10.1016/j.jiec.2015.12.004

Cite this

@article{222034b323334909b0d46f96dfa35823,

title = "Synthesis of high porous electrospun hollow TiO2 nanofibers for bone tissue engineering application",

abstract = "Highly porous, hollow TiO2 nanofibers (NFs) were fabricated through coaxial nozzle electrospinning using a polymer sol-gel solution of CaCO3 and TiO2 precursor. Hollow and porous TiO2 NFs were obtained by etching CaCO3 on calcined TiO2 fibers using dilute HCl. Characterization of the as-synthesized materials were performed using FE-SEM and XRD before and after 24 h of bio-mineralization. The in vitro cell culture test was performed using MC3T3-E1 osteoblast cells to assess cell response of the different NFs. The results suggested that as-synthesized porous nanotubes have better biocompatibility for bone regeneration and implantations compared to other nonporous TiO2 nanorods or NFs.",

keywords = "Biomaterials, Bone tissue engineering, Coaxial electrospinning, Nanotubes, TiO",

author = "Adhikari, \{Surya Prasad\} and Pant, \{Hem Raj\} and Mousa, \{Hamouda M.\} and Joshua Lee and Kim, \{Han Joo\} and Park, \{Chan Hee\} and Kim, \{Cheol Sang\}",

note = "Publisher Copyright: {\textcopyright} 2015 The Korean Society of Industrial and Engineering Chemistry.",

year = "2016",

month = mar,

day = "25",

doi = "10.1016/j.jiec.2015.12.004",

language = "English",

volume = "35",

pages = "75--82",

journal = "Journal of Industrial and Engineering Chemistry",

issn = "1226-086X",

}

TY - JOUR

T1 - Synthesis of high porous electrospun hollow TiO2 nanofibers for bone tissue engineering application

AU - Adhikari, Surya Prasad

AU - Pant, Hem Raj

AU - Mousa, Hamouda M.

AU - Lee, Joshua

AU - Kim, Han Joo

AU - Park, Chan Hee

AU - Kim, Cheol Sang

PY - 2016/3/25

Y1 - 2016/3/25

N2 - Highly porous, hollow TiO2 nanofibers (NFs) were fabricated through coaxial nozzle electrospinning using a polymer sol-gel solution of CaCO3 and TiO2 precursor. Hollow and porous TiO2 NFs were obtained by etching CaCO3 on calcined TiO2 fibers using dilute HCl. Characterization of the as-synthesized materials were performed using FE-SEM and XRD before and after 24 h of bio-mineralization. The in vitro cell culture test was performed using MC3T3-E1 osteoblast cells to assess cell response of the different NFs. The results suggested that as-synthesized porous nanotubes have better biocompatibility for bone regeneration and implantations compared to other nonporous TiO2 nanorods or NFs.

AB - Highly porous, hollow TiO2 nanofibers (NFs) were fabricated through coaxial nozzle electrospinning using a polymer sol-gel solution of CaCO3 and TiO2 precursor. Hollow and porous TiO2 NFs were obtained by etching CaCO3 on calcined TiO2 fibers using dilute HCl. Characterization of the as-synthesized materials were performed using FE-SEM and XRD before and after 24 h of bio-mineralization. The in vitro cell culture test was performed using MC3T3-E1 osteoblast cells to assess cell response of the different NFs. The results suggested that as-synthesized porous nanotubes have better biocompatibility for bone regeneration and implantations compared to other nonporous TiO2 nanorods or NFs.

KW - Biomaterials

KW - Bone tissue engineering

KW - Coaxial electrospinning

KW - Nanotubes

KW - TiO

UR - https://www.scopus.com/pages/publications/84959488441

U2 - 10.1016/j.jiec.2015.12.004

DO - 10.1016/j.jiec.2015.12.004

M3 - Journal article

AN - SCOPUS:84959488441

SN - 1226-086X

VL - 35

SP - 75

EP - 82

JO - Journal of Industrial and Engineering Chemistry

JF - Journal of Industrial and Engineering Chemistry

ER -