Abstract
Novel anthracycline analogues 2-9 as potential anticancer agents were synthesized from daunomycin (1a) and doxorubicin (1b). Compounds 2, 6, and 7 were prepared by the nucleophilic displacement type esterification of a 14-bromodaunomycin (1c) with a sodium lactate, and stearic acid, respectively. Compounds 3-5 and 7-9 were prepared by the reaction of either daunomycin (1a) or doxorubicin (1b) with L-lactic and stearic acids in the presence of EDCI/PP reagents.
| Original language | English |
|---|---|
| Pages (from-to) | 1359-1363 |
| Number of pages | 5 |
| Journal | Bulletin of the Korean Chemical Society |
| Volume | 27 |
| Issue number | 9 |
| DOIs | |
| State | Published - 2006.09.20 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Anthracycline derivatives
- Daunomycin
- Doxorubicin
- Lactic acid
- Stearic acid
Quacquarelli Symonds(QS) Subject Topics
- Chemistry
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