TBG-136, a Schizophyllum commune-derived β-glucan benefits gut microbiota and intestinal health: A randomized, double-blind, and placebo-controlled clinical trial

Hui Yeon Jang; Su Jin Jung; Eun Ock Park; Soo Dong Kim; Je Kyoung Kim; Soo Wan Chae; Youn–Soo –S Cha; Seung Ok Lee

doi:10.1016/j.jff.2023.105668

TBG-136, a Schizophyllum commune-derived β-glucan benefits gut microbiota and intestinal health: A randomized, double-blind, and placebo-controlled clinical trial

Hui Yeon Jang
, Su Jin Jung
, Eun Ock Park
, Soo Dong Kim
, Je Kyoung Kim
, Soo Wan Chae
, Youn–Soo –S Cha^*
, Seung Ok Lee

^*Corresponding author for this work

Department of Medicine

Research output: Contribution to journal › Journal article › peer-review

10 Scopus citations

Abstract

β-glucan exerts beneficial biological activities such as immunoregulatory, anticancer, antioxidative, antiaging, and wound healing. However, the effects of β-glucan on constipation have not been thoroughly studied. Thus, the present study aimed to investigate the effects of β-glucan-derived from Schizophyllum commune supplementation (TBG-136) on gut microbiota and intestinal health in constipated subjects. As a result, Lactobacillus was significantly increased in the TBG-136 group compared to the placebo group (P < 0.05) after 8 weeks of TBG-136 supplementation. Additionally, TBG-136 group significantly improved the rectosigmoid CTT and the number of defecations compared to the placebo group (P < 0.05). Thus, β-glucan derived from Schizophyllum commune helps individuals' health and quality of life by increasing the beneficial bacteria and improving symptoms of constipation.

Original language	English
Article number	105668
Journal	Journal of Functional Foods
Volume	107
DOIs	https://doi.org/10.1016/j.jff.2023.105668
State	Published - 2023.08

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Constipation
Gut bacteria
Intestinal health
Schizophyllum commune
β-glucan

Quacquarelli Symonds(QS) Subject Topics

Nursing
Agriculture & Forestry
Medicine

Access to Document

10.1016/j.jff.2023.105668

Cite this

@article{c03ee2160e8c451b97584240ab86c260,

title = "TBG-136, a Schizophyllum commune-derived β-glucan benefits gut microbiota and intestinal health: A randomized, double-blind, and placebo-controlled clinical trial",

abstract = "β-glucan exerts beneficial biological activities such as immunoregulatory, anticancer, antioxidative, antiaging, and wound healing. However, the effects of β-glucan on constipation have not been thoroughly studied. Thus, the present study aimed to investigate the effects of β-glucan-derived from Schizophyllum commune supplementation (TBG-136) on gut microbiota and intestinal health in constipated subjects. As a result, Lactobacillus was significantly increased in the TBG-136 group compared to the placebo group (P < 0.05) after 8 weeks of TBG-136 supplementation. Additionally, TBG-136 group significantly improved the rectosigmoid CTT and the number of defecations compared to the placebo group (P < 0.05). Thus, β-glucan derived from Schizophyllum commune helps individuals' health and quality of life by increasing the beneficial bacteria and improving symptoms of constipation.",

keywords = "Constipation, Gut bacteria, Intestinal health, Schizophyllum commune, β-glucan",

author = "Jang, \{Hui Yeon\} and Jung, \{Su Jin\} and Park, \{Eun Ock\} and Kim, \{Soo Dong\} and Kim, \{Je Kyoung\} and Chae, \{Soo Wan\} and Cha, \{Youn–Soo –S\} and Lee, \{Seung Ok\}",

note = "Publisher Copyright: {\textcopyright} 2023",

year = "2023",

month = aug,

doi = "10.1016/j.jff.2023.105668",

language = "English",

volume = "107",

journal = "Journal of Functional Foods",

issn = "1756-4646",

}

TY - JOUR

T1 - TBG-136, a Schizophyllum commune-derived β-glucan benefits gut microbiota and intestinal health

T2 - A randomized, double-blind, and placebo-controlled clinical trial

AU - Jang, Hui Yeon

AU - Jung, Su Jin

AU - Park, Eun Ock

AU - Kim, Soo Dong

AU - Kim, Je Kyoung

AU - Chae, Soo Wan

AU - Cha, Youn–Soo –S

AU - Lee, Seung Ok

PY - 2023/8

Y1 - 2023/8

N2 - β-glucan exerts beneficial biological activities such as immunoregulatory, anticancer, antioxidative, antiaging, and wound healing. However, the effects of β-glucan on constipation have not been thoroughly studied. Thus, the present study aimed to investigate the effects of β-glucan-derived from Schizophyllum commune supplementation (TBG-136) on gut microbiota and intestinal health in constipated subjects. As a result, Lactobacillus was significantly increased in the TBG-136 group compared to the placebo group (P < 0.05) after 8 weeks of TBG-136 supplementation. Additionally, TBG-136 group significantly improved the rectosigmoid CTT and the number of defecations compared to the placebo group (P < 0.05). Thus, β-glucan derived from Schizophyllum commune helps individuals' health and quality of life by increasing the beneficial bacteria and improving symptoms of constipation.

AB - β-glucan exerts beneficial biological activities such as immunoregulatory, anticancer, antioxidative, antiaging, and wound healing. However, the effects of β-glucan on constipation have not been thoroughly studied. Thus, the present study aimed to investigate the effects of β-glucan-derived from Schizophyllum commune supplementation (TBG-136) on gut microbiota and intestinal health in constipated subjects. As a result, Lactobacillus was significantly increased in the TBG-136 group compared to the placebo group (P < 0.05) after 8 weeks of TBG-136 supplementation. Additionally, TBG-136 group significantly improved the rectosigmoid CTT and the number of defecations compared to the placebo group (P < 0.05). Thus, β-glucan derived from Schizophyllum commune helps individuals' health and quality of life by increasing the beneficial bacteria and improving symptoms of constipation.

KW - Constipation

KW - Gut bacteria

KW - Intestinal health

KW - Schizophyllum commune

KW - β-glucan

UR - https://www.scopus.com/pages/publications/85165252593

U2 - 10.1016/j.jff.2023.105668

DO - 10.1016/j.jff.2023.105668

M3 - Journal article

AN - SCOPUS:85165252593

SN - 1756-4646

VL - 107

JO - Journal of Functional Foods

JF - Journal of Functional Foods

M1 - 105668

ER -

TBG-136, a Schizophyllum commune-derived β-glucan benefits gut microbiota and intestinal health: A randomized, double-blind, and placebo-controlled clinical trial

Abstract

UN SDGs

Keywords

Quacquarelli Symonds(QS) Subject Topics

Access to Document

Other files and links

Fingerprint

Report Summarizes Functional Foods Study Findings from Jeonbuk National University (Tbg-136, a Schizophyllum Commune-derived Beta-glucan Benefits Gut Microbiota and Intestinal Health: a Randomized, Double-blind, and Placebo-controlled Clinical ...)

Cite this

TBG-136, a Schizophyllum commune-derived β-glucan benefits gut microbiota and intestinal health: A randomized, double-blind, and placebo-controlled clinical trial

Abstract

UN SDGs

Keywords

Quacquarelli Symonds(QS) Subject Topics

Access to Document

Other files and links

Fingerprint

Press/Media

Report Summarizes Functional Foods Study Findings from Jeonbuk National University (Tbg-136, a Schizophyllum Commune-derived Beta-glucan Benefits Gut Microbiota and Intestinal Health: a Randomized, Double-blind, and Placebo-controlled Clinical ...)

Cite this