The biological and pharmacological roles of polyphenol flavonoid tilianin

Archaeological evidence for phytomedicine has established the importance of plants as a source of biologically active molecules with beneficial effects. Related studies constitute significant tools for novel drug discovery. A major benefit of phytomedicine is that standard ethnopharmacological evidence regarding traditional uses can give indications for molecules that may be therapeutically significant. Tilianin is a polyphenol antioxidant commonly used as natural phytomedicine. At the molecular level, tilianin has been reported to modulate a number of key elements in cellular signal transduction pathways linked to oxidative stress-mediated inflammation, apoptosis, and angiogenesis. At present review, we address potential approaches for arbitrating novel tilianin biologics in medicinal applications, concentrating on the selection of personalized medicines and emphasizing tasks and prospects related to medical discoveries over the last few years. In particular, we highlight the major health benefits of tilianin, which comprise cardioprotective, neuroprotective, anti-atherogenic, anti-hypertensive, anti-diabetes, anti-inflammatory, antioxidant, anti-depressant, and miscellaneous aspects.