The characterization of PLGA/small intestinal submucosa composites as scaffolds for intervertebral disc

Soon Hee Kim; Bang Sil Choi; Youn Kyung Ko; Hyun Jung Ha; Sun Jung Yoon; John M. Rhee; Moon Suk Kim; Hai Bang Lee; Gilson Khang

doi:10.4028/0-87849-436-7.389

The characterization of PLGA/small intestinal submucosa composites as scaffolds for intervertebral disc

Soon Hee Kim^*
, Bang Sil Choi
, Youn Kyung Ko
, Hyun Jung Ha
, Sun Jung Yoon
, John M. Rhee
, Moon Suk Kim
, Hai Bang Lee
, Gilson Khang

^*Corresponding author for this work

Jeonbuk National University
Korea Research Institute of Chemical Technology

Research output: Contribution to journal › Journal article › peer-review

6 Scopus citations

Abstract

In order to application for the tissue engineered intervertebral disc (IVD), we designed the synthetic/natural hybrid scaffolds with poly(lactide-co-glycolide) (PLGA) and small intestine submucosa (SIS). SIS has been widely used as a biomaterial because SIS consists of various collagens and cytokines. SIS, however, possesses disadvantages such as their weak mechanical properties and uncontrolled degradation. Novel composite scaffolds of PLGA/SIS were manufactured by simple immersion method of PLGA scaffolds in SIS solution under vacuum. Then SIS was crosslinked. Also, PLGA scaffolds and SIS sponges were manufactured by solvent casting/salt leaching and freeze-dried methods, respectively. We evaluated pore structure, porosity, water absorption ability and cell viability of three types of scaffolds for the application of IVD.

Original language	English
Pages (from-to)	389-392
Number of pages	4
Journal	Key Engineering Materials
Volume	342-343
DOIs	https://doi.org/10.4028/0-87849-436-7.389
State	Published - 2007

Keywords

FTIR
MTT assay
PLGA
Pore size
Small intestinal submucosa

Quacquarelli Symonds(QS) Subject Topics

Materials Science
Engineering - Mechanical

Access to Document

10.4028/0-87849-436-7.389

Cite this

@article{36d925f42b5440bfa686ff1fa77ec1e6,

title = "The characterization of PLGA/small intestinal submucosa composites as scaffolds for intervertebral disc",

abstract = "In order to application for the tissue engineered intervertebral disc (IVD), we designed the synthetic/natural hybrid scaffolds with poly(lactide-co-glycolide) (PLGA) and small intestine submucosa (SIS). SIS has been widely used as a biomaterial because SIS consists of various collagens and cytokines. SIS, however, possesses disadvantages such as their weak mechanical properties and uncontrolled degradation. Novel composite scaffolds of PLGA/SIS were manufactured by simple immersion method of PLGA scaffolds in SIS solution under vacuum. Then SIS was crosslinked. Also, PLGA scaffolds and SIS sponges were manufactured by solvent casting/salt leaching and freeze-dried methods, respectively. We evaluated pore structure, porosity, water absorption ability and cell viability of three types of scaffolds for the application of IVD.",

keywords = "FTIR, MTT assay, PLGA, Pore size, Small intestinal submucosa",

author = "Kim, \{Soon Hee\} and Choi, \{Bang Sil\} and Ko, \{Youn Kyung\} and Ha, \{Hyun Jung\} and Yoon, \{Sun Jung\} and Rhee, \{John M.\} and Kim, \{Moon Suk\} and Lee, \{Hai Bang\} and Gilson Khang",

year = "2007",

doi = "10.4028/0-87849-436-7.389",

language = "English",

volume = "342-343",

pages = "389--392",

journal = "Key Engineering Materials",

issn = "1013-9826",

}

TY - JOUR

T1 - The characterization of PLGA/small intestinal submucosa composites as scaffolds for intervertebral disc

AU - Kim, Soon Hee

AU - Choi, Bang Sil

AU - Ko, Youn Kyung

AU - Ha, Hyun Jung

AU - Yoon, Sun Jung

AU - Rhee, John M.

AU - Kim, Moon Suk

AU - Lee, Hai Bang

AU - Khang, Gilson

PY - 2007

Y1 - 2007

N2 - In order to application for the tissue engineered intervertebral disc (IVD), we designed the synthetic/natural hybrid scaffolds with poly(lactide-co-glycolide) (PLGA) and small intestine submucosa (SIS). SIS has been widely used as a biomaterial because SIS consists of various collagens and cytokines. SIS, however, possesses disadvantages such as their weak mechanical properties and uncontrolled degradation. Novel composite scaffolds of PLGA/SIS were manufactured by simple immersion method of PLGA scaffolds in SIS solution under vacuum. Then SIS was crosslinked. Also, PLGA scaffolds and SIS sponges were manufactured by solvent casting/salt leaching and freeze-dried methods, respectively. We evaluated pore structure, porosity, water absorption ability and cell viability of three types of scaffolds for the application of IVD.

AB - In order to application for the tissue engineered intervertebral disc (IVD), we designed the synthetic/natural hybrid scaffolds with poly(lactide-co-glycolide) (PLGA) and small intestine submucosa (SIS). SIS has been widely used as a biomaterial because SIS consists of various collagens and cytokines. SIS, however, possesses disadvantages such as their weak mechanical properties and uncontrolled degradation. Novel composite scaffolds of PLGA/SIS were manufactured by simple immersion method of PLGA scaffolds in SIS solution under vacuum. Then SIS was crosslinked. Also, PLGA scaffolds and SIS sponges were manufactured by solvent casting/salt leaching and freeze-dried methods, respectively. We evaluated pore structure, porosity, water absorption ability and cell viability of three types of scaffolds for the application of IVD.

KW - FTIR

KW - MTT assay

KW - PLGA

KW - Pore size

KW - Small intestinal submucosa

UR - https://www.scopus.com/pages/publications/34147190991

U2 - 10.4028/0-87849-436-7.389

DO - 10.4028/0-87849-436-7.389

M3 - Journal article

AN - SCOPUS:34147190991

SN - 1013-9826

VL - 342-343

SP - 389

EP - 392

JO - Key Engineering Materials

JF - Key Engineering Materials

ER -

The characterization of PLGA/small intestinal submucosa composites as scaffolds for intervertebral disc

Abstract

Keywords

Quacquarelli Symonds(QS) Subject Topics

Access to Document

Other files and links

Fingerprint

Cite this