The effect of bead size and semipermeable layer thickness on drug release from nifedipine-osmotic granule system

Jae Song Cho; Ju Yong Youn; Byung Soo Kim; Jae Min Oh; Moon Suk Kim; Gilson Khang; Hai Bang Lee

The effect of bead size and semipermeable layer thickness on drug release from nifedipine-osmotic granule system

Jae Song Cho
, Ju Yong Youn
, Byung Soo Kim
, Jae Min Oh
, Moon Suk Kim
, Gilson Khang
, Hai Bang Lee

Department of Polymer -Nano Science &Technology

Korea Research Institute of Chemical Technology
Jeonbuk National University

Research output: Contribution to journal › Journal article › peer-review

5 Scopus citations

Abstract

Osmotic granule, which consisted of water-swellable seed layer, drug layer, and porous membrane layer, has been widely utilized in oral drug delivery system. In this work, we describe the preparation of osmotic granule with nifedipine as model drug and a mixture of cellulose acetate(CA) and Eudragit RL as membrane layer, and then examined the drug release behavior on the variation of the thickness change of membrane layer(CA and Eudragit RL) and release media.

Original language	English
Pages (from-to)	242-247
Number of pages	6
Journal	Tissue Engineering and Regenerative Medicine
Volume	5
Issue number	2
State	Published - 2008.06

Keywords

Cellulose acetate
Endragit RL
Nifedifine
Osmotic granule
Thickness

Quacquarelli Symonds(QS) Subject Topics

Medicine
Biological Sciences

Cite this

@article{408e7bf394d74004a03ff9f9588b8488,

title = "The effect of bead size and semipermeable layer thickness on drug release from nifedipine-osmotic granule system",

abstract = "Osmotic granule, which consisted of water-swellable seed layer, drug layer, and porous membrane layer, has been widely utilized in oral drug delivery system. In this work, we describe the preparation of osmotic granule with nifedipine as model drug and a mixture of cellulose acetate(CA) and Eudragit RL as membrane layer, and then examined the drug release behavior on the variation of the thickness change of membrane layer(CA and Eudragit RL) and release media.",

keywords = "Cellulose acetate, Endragit RL, Nifedifine, Osmotic granule, Thickness",

author = "Cho, \{Jae Song\} and Youn, \{Ju Yong\} and Kim, \{Byung Soo\} and Oh, \{Jae Min\} and Kim, \{Moon Suk\} and Gilson Khang and Lee, \{Hai Bang\}",

year = "2008",

month = jun,

language = "English",

volume = "5",

pages = "242--247",

journal = "Tissue Engineering and Regenerative Medicine",

issn = "1738-2696",

number = "2",

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TY - JOUR

T1 - The effect of bead size and semipermeable layer thickness on drug release from nifedipine-osmotic granule system

AU - Cho, Jae Song

AU - Youn, Ju Yong

AU - Kim, Byung Soo

AU - Oh, Jae Min

AU - Kim, Moon Suk

AU - Khang, Gilson

AU - Lee, Hai Bang

PY - 2008/6

Y1 - 2008/6

N2 - Osmotic granule, which consisted of water-swellable seed layer, drug layer, and porous membrane layer, has been widely utilized in oral drug delivery system. In this work, we describe the preparation of osmotic granule with nifedipine as model drug and a mixture of cellulose acetate(CA) and Eudragit RL as membrane layer, and then examined the drug release behavior on the variation of the thickness change of membrane layer(CA and Eudragit RL) and release media.

AB - Osmotic granule, which consisted of water-swellable seed layer, drug layer, and porous membrane layer, has been widely utilized in oral drug delivery system. In this work, we describe the preparation of osmotic granule with nifedipine as model drug and a mixture of cellulose acetate(CA) and Eudragit RL as membrane layer, and then examined the drug release behavior on the variation of the thickness change of membrane layer(CA and Eudragit RL) and release media.

KW - Cellulose acetate

KW - Endragit RL

KW - Nifedifine

KW - Osmotic granule

KW - Thickness

UR - https://www.scopus.com/pages/publications/79955509327

M3 - Journal article

AN - SCOPUS:79955509327

SN - 1738-2696

VL - 5

SP - 242

EP - 247

JO - Tissue Engineering and Regenerative Medicine

JF - Tissue Engineering and Regenerative Medicine

IS - 2

ER -

The effect of bead size and semipermeable layer thickness on drug release from nifedipine-osmotic granule system

Abstract

Keywords

Quacquarelli Symonds(QS) Subject Topics

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