The Effect of Gamma Irradiation on PLGA and Release Behavior of BCNU from PLGA Wafer

Jin Soo Lee; Gang Soo Chae; Gilson Khang; Moon Suk Kim; Sun Hang Cho; Hai Bang Lee

doi:10.1007/BF03218376

The Effect of Gamma Irradiation on PLGA and Release Behavior of BCNU from PLGA Wafer

Jin Soo Lee^*
, Gang Soo Chae
, Gilson Khang
, Moon Suk Kim
, Sun Hang Cho
, Hai Bang Lee

^*Corresponding author for this work

Department of Polymer -Nano Science &Technology

Research output: Contribution to journal › Journal article › peer-review

26 Scopus citations

Abstract

The objectives of this study were to investigate the influence of gamma irradiation for sterilization on poly(D,L-lactide-co-glycolide) (PLGA) with different molecular weight and the effect of gamma irradiation on the release behavior of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU, carmustine) from PLGA wafer with various irradiation doses. The effect of gamma irradiation on PLGA was evaluated by gel permeation chromatography (GPC), differential scanning calorimetry (DSC), and electron paramagnetic resonance (EPR). The weight average molecular weight (M_w) and glass transition temperature (T_g) of PLGA decreased after gamma irradiation. The extent of M _w reduction was dependent on irradiation dose and PLGA molecular weight. Using EPR spectroscopy, we successfully detected gamma irradiation induced free radicals in PLGA. The gamma irradiation increased the release rate of BCNU from PLGA wafer at applied irradiation doses except 2.5 Mrad of irradiation dose in this study.

Original language	English
Pages (from-to)	352-356
Number of pages	5
Journal	Macromolecular Research
Volume	11
Issue number	5
DOIs	https://doi.org/10.1007/BF03218376
State	Published - 2003.10

Keywords

BCNU
Free radical
Gamma irradiation
Molecular weight
PLGA wafer
Release profile

Quacquarelli Symonds(QS) Subject Topics

Materials Science
Engineering - Petroleum
Engineering - Chemical
Chemistry

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10.1007/BF03218376

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@article{ebb1d38afef94b2c92638e5cac1cbd4a,

title = "The Effect of Gamma Irradiation on PLGA and Release Behavior of BCNU from PLGA Wafer",

abstract = "The objectives of this study were to investigate the influence of gamma irradiation for sterilization on poly(D,L-lactide-co-glycolide) (PLGA) with different molecular weight and the effect of gamma irradiation on the release behavior of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU, carmustine) from PLGA wafer with various irradiation doses. The effect of gamma irradiation on PLGA was evaluated by gel permeation chromatography (GPC), differential scanning calorimetry (DSC), and electron paramagnetic resonance (EPR). The weight average molecular weight (Mw) and glass transition temperature (Tg) of PLGA decreased after gamma irradiation. The extent of M w reduction was dependent on irradiation dose and PLGA molecular weight. Using EPR spectroscopy, we successfully detected gamma irradiation induced free radicals in PLGA. The gamma irradiation increased the release rate of BCNU from PLGA wafer at applied irradiation doses except 2.5 Mrad of irradiation dose in this study.",

keywords = "BCNU, Free radical, Gamma irradiation, Molecular weight, PLGA wafer, Release profile",

author = "Lee, \{Jin Soo\} and Chae, \{Gang Soo\} and Gilson Khang and Kim, \{Moon Suk\} and Cho, \{Sun Hang\} and Lee, \{Hai Bang\}",

year = "2003",

month = oct,

doi = "10.1007/BF03218376",

language = "English",

volume = "11",

pages = "352--356",

journal = "Macromolecular Research",

issn = "1598-5032",

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TY - JOUR

T1 - The Effect of Gamma Irradiation on PLGA and Release Behavior of BCNU from PLGA Wafer

AU - Lee, Jin Soo

AU - Chae, Gang Soo

AU - Khang, Gilson

AU - Kim, Moon Suk

AU - Cho, Sun Hang

AU - Lee, Hai Bang

PY - 2003/10

Y1 - 2003/10

N2 - The objectives of this study were to investigate the influence of gamma irradiation for sterilization on poly(D,L-lactide-co-glycolide) (PLGA) with different molecular weight and the effect of gamma irradiation on the release behavior of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU, carmustine) from PLGA wafer with various irradiation doses. The effect of gamma irradiation on PLGA was evaluated by gel permeation chromatography (GPC), differential scanning calorimetry (DSC), and electron paramagnetic resonance (EPR). The weight average molecular weight (Mw) and glass transition temperature (Tg) of PLGA decreased after gamma irradiation. The extent of M w reduction was dependent on irradiation dose and PLGA molecular weight. Using EPR spectroscopy, we successfully detected gamma irradiation induced free radicals in PLGA. The gamma irradiation increased the release rate of BCNU from PLGA wafer at applied irradiation doses except 2.5 Mrad of irradiation dose in this study.

AB - The objectives of this study were to investigate the influence of gamma irradiation for sterilization on poly(D,L-lactide-co-glycolide) (PLGA) with different molecular weight and the effect of gamma irradiation on the release behavior of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU, carmustine) from PLGA wafer with various irradiation doses. The effect of gamma irradiation on PLGA was evaluated by gel permeation chromatography (GPC), differential scanning calorimetry (DSC), and electron paramagnetic resonance (EPR). The weight average molecular weight (Mw) and glass transition temperature (Tg) of PLGA decreased after gamma irradiation. The extent of M w reduction was dependent on irradiation dose and PLGA molecular weight. Using EPR spectroscopy, we successfully detected gamma irradiation induced free radicals in PLGA. The gamma irradiation increased the release rate of BCNU from PLGA wafer at applied irradiation doses except 2.5 Mrad of irradiation dose in this study.

KW - BCNU

KW - Free radical

KW - Gamma irradiation

KW - Molecular weight

KW - PLGA wafer

KW - Release profile

UR - https://www.scopus.com/pages/publications/0242438527

U2 - 10.1007/BF03218376

DO - 10.1007/BF03218376

M3 - Journal article

AN - SCOPUS:0242438527

SN - 1598-5032

VL - 11

SP - 352

EP - 356

JO - Macromolecular Research

JF - Macromolecular Research

IS - 5

ER -

The Effect of Gamma Irradiation on PLGA and Release Behavior of BCNU from PLGA Wafer

Abstract

Keywords

Quacquarelli Symonds(QS) Subject Topics

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