The effect of molecular weight of drugs on transdermal delivery system using microneedle device

Chang Rae Lee; Moon Suk Kim; Hai Bang Lee; Han Ku Lee; John M. Rhee; Gilson Khang

doi:10.4028/0-87849-436-7.945

The effect of molecular weight of drugs on transdermal delivery system using microneedle device

Chang Rae Lee^*
, Moon Suk Kim
, Hai Bang Lee
, Han Ku Lee
, John M. Rhee
, Gilson Khang

^*Corresponding author for this work

Department of Polymer -Nano Science &Technology

Jeonbuk National University
Korea Research Institute of Chemical Technology
DS and G

Research output: Contribution to journal › Journal article › peer-review

10 Scopus citations

Abstract

We developed the successive roller type of microneedle system without pain to improve the permeation of drug through the skin barrier. The permeation rates of FITC-ovalbumin (OVA, MW: 45,000g/mole), FITC-insulin (MW: 5,733 g/mole) and FITC-bufexamac (MW: 227.37 g/mole) as model drugs were determined by modified Franz diffusion cells using the microneedle device with four times treatment. The average penetration fluxes of FITC- OVA, FITC-insulin and FITC-bufexamac were steeply increased from 13.4 to 83.3, 10.1 to 110.6 and 11.9 to 242.6 pmol/cm² with treatment for 12 hrs, respectively. The lower the molecular weight of the drugs, the more the permeation flux investigated. In conclusion, we confirmed the possibility of the application for transdermal delivery of the larger molecular drugs as protein using the designed microneedle treatment device.

Original language	English
Pages (from-to)	945-948
Number of pages	4
Journal	Key Engineering Materials
Volume	342-343
DOIs	https://doi.org/10.4028/0-87849-436-7.945
State	Published - 2007

Keywords

Bufexamac
Insulin
Microneedle system
Molecular weight
OVA
Transdermal system

Quacquarelli Symonds(QS) Subject Topics

Engineering - Mechanical
Materials Science

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10.4028/0-87849-436-7.945

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@article{3c876473363b45218bbbd9ea96f603a2,

title = "The effect of molecular weight of drugs on transdermal delivery system using microneedle device",

abstract = "We developed the successive roller type of microneedle system without pain to improve the permeation of drug through the skin barrier. The permeation rates of FITC-ovalbumin (OVA, MW: 45,000g/mole), FITC-insulin (MW: 5,733 g/mole) and FITC-bufexamac (MW: 227.37 g/mole) as model drugs were determined by modified Franz diffusion cells using the microneedle device with four times treatment. The average penetration fluxes of FITC- OVA, FITC-insulin and FITC-bufexamac were steeply increased from 13.4 to 83.3, 10.1 to 110.6 and 11.9 to 242.6 pmol/cm2 with treatment for 12 hrs, respectively. The lower the molecular weight of the drugs, the more the permeation flux investigated. In conclusion, we confirmed the possibility of the application for transdermal delivery of the larger molecular drugs as protein using the designed microneedle treatment device.",

keywords = "Bufexamac, Insulin, Microneedle system, Molecular weight, OVA, Transdermal system",

author = "Lee, \{Chang Rae\} and Kim, \{Moon Suk\} and Lee, \{Hai Bang\} and Lee, \{Han Ku\} and Rhee, \{John M.\} and Gilson Khang",

year = "2007",

doi = "10.4028/0-87849-436-7.945",

language = "English",

volume = "342-343",

pages = "945--948",

journal = "Key Engineering Materials",

issn = "1013-9826",

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TY - JOUR

T1 - The effect of molecular weight of drugs on transdermal delivery system using microneedle device

AU - Lee, Chang Rae

AU - Kim, Moon Suk

AU - Lee, Hai Bang

AU - Lee, Han Ku

AU - Rhee, John M.

AU - Khang, Gilson

PY - 2007

Y1 - 2007

N2 - We developed the successive roller type of microneedle system without pain to improve the permeation of drug through the skin barrier. The permeation rates of FITC-ovalbumin (OVA, MW: 45,000g/mole), FITC-insulin (MW: 5,733 g/mole) and FITC-bufexamac (MW: 227.37 g/mole) as model drugs were determined by modified Franz diffusion cells using the microneedle device with four times treatment. The average penetration fluxes of FITC- OVA, FITC-insulin and FITC-bufexamac were steeply increased from 13.4 to 83.3, 10.1 to 110.6 and 11.9 to 242.6 pmol/cm2 with treatment for 12 hrs, respectively. The lower the molecular weight of the drugs, the more the permeation flux investigated. In conclusion, we confirmed the possibility of the application for transdermal delivery of the larger molecular drugs as protein using the designed microneedle treatment device.

AB - We developed the successive roller type of microneedle system without pain to improve the permeation of drug through the skin barrier. The permeation rates of FITC-ovalbumin (OVA, MW: 45,000g/mole), FITC-insulin (MW: 5,733 g/mole) and FITC-bufexamac (MW: 227.37 g/mole) as model drugs were determined by modified Franz diffusion cells using the microneedle device with four times treatment. The average penetration fluxes of FITC- OVA, FITC-insulin and FITC-bufexamac were steeply increased from 13.4 to 83.3, 10.1 to 110.6 and 11.9 to 242.6 pmol/cm2 with treatment for 12 hrs, respectively. The lower the molecular weight of the drugs, the more the permeation flux investigated. In conclusion, we confirmed the possibility of the application for transdermal delivery of the larger molecular drugs as protein using the designed microneedle treatment device.

KW - Bufexamac

KW - Insulin

KW - Microneedle system

KW - Molecular weight

KW - OVA

KW - Transdermal system

UR - https://www.scopus.com/pages/publications/34147187339

U2 - 10.4028/0-87849-436-7.945

DO - 10.4028/0-87849-436-7.945

M3 - Journal article

AN - SCOPUS:34147187339

SN - 1013-9826

VL - 342-343

SP - 945

EP - 948

JO - Key Engineering Materials

JF - Key Engineering Materials

ER -

The effect of molecular weight of drugs on transdermal delivery system using microneedle device

Abstract

Keywords

Quacquarelli Symonds(QS) Subject Topics

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