The Gad mouse: A window into UPS-related neurodegeneration and the function of the function of the deubiquitinating enzyme UCH-L1

Jungkee Kwon; Keiji Wada

doi:10.1007/0-387-28500-8_11

The Gad mouse: A window into UPS-related neurodegeneration and the function of the function of the deubiquitinating enzyme UCH-L1

Jungkee Kwon
, Keiji Wada

Department of Veterinary Medicine

National Center of Neurology and Psychiatry Kodaira

Research output: Contribution to conference › Chapter › peer-review

2 Scopus citations

Abstract

The role of UCH-L1 in neuronal function is becoming more apparent with the use of refined cellular and molecular approaches and several in vitro and in vivo model systems. Although the I93M-UCH-L1 mutant and S18Y-UCH-L1 variant are clearly involved in the pathogenesis of PD, our understanding of the underlying molecular mechanisms of UCH-L1 function is still limited. Further investigation of the relationship between neurodegeneration and UCH-L1 modifications should help to elucidate the mechanisms of pathogenesis in PD and AD and may suggest novel targets for therapeutic intervention.

Original language	English
Title of host publication	The Proteasome in Neurodegeneration
Publisher	Springer US
Pages	185-198
Number of pages	14
ISBN (Electronic)	9780387285009
ISBN (Print)	9780387284996
DOIs	https://doi.org/10.1007/0-387-28500-8_11
State	Published - 2006

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abstract = "The role of UCH-L1 in neuronal function is becoming more apparent with the use of refined cellular and molecular approaches and several in vitro and in vivo model systems. Although the I93M-UCH-L1 mutant and S18Y-UCH-L1 variant are clearly involved in the pathogenesis of PD, our understanding of the underlying molecular mechanisms of UCH-L1 function is still limited. Further investigation of the relationship between neurodegeneration and UCH-L1 modifications should help to elucidate the mechanisms of pathogenesis in PD and AD and may suggest novel targets for therapeutic intervention.",

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AB - The role of UCH-L1 in neuronal function is becoming more apparent with the use of refined cellular and molecular approaches and several in vitro and in vivo model systems. Although the I93M-UCH-L1 mutant and S18Y-UCH-L1 variant are clearly involved in the pathogenesis of PD, our understanding of the underlying molecular mechanisms of UCH-L1 function is still limited. Further investigation of the relationship between neurodegeneration and UCH-L1 modifications should help to elucidate the mechanisms of pathogenesis in PD and AD and may suggest novel targets for therapeutic intervention.

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PB - Springer US

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The Gad mouse: A window into UPS-related neurodegeneration and the function of the function of the deubiquitinating enzyme UCH-L1

Abstract

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