The immune-stimulating peptide WKYMVm has therapeutic effects against ulcerative colitis

Sang Doo Kim; Soonil Kwon; Sung Kyun Lee; Minsoo Kook; Ha Young Lee; Ki Duk Song; Hak Kyo Lee; Suk Hwan Baek; Chan Bae Park; Yoe Sik Bae

doi:10.1038/emm.2013.77

The immune-stimulating peptide WKYMVm has therapeutic effects against ulcerative colitis

Sang Doo Kim
, Soonil Kwon
, Sung Kyun Lee
, Minsoo Kook
, Ha Young Lee
, Ki Duk Song
, Hak Kyo Lee
, Suk Hwan Baek
, Chan Bae Park
, Yoe Sik Bae^*

^*Corresponding author for this work

Department of Agricultural Convergence Technology

Sungkyunkwan University
Dong-A University
Hankyong National University
Yeungnam University
Ajou University

Research output: Contribution to journal › Journal article › peer-review

39 Scopus citations

Abstract

In this study, we examined the therapeutic effects of an immune-stimulating peptide, WKYMVm, in ulcerative colitis. The administration of WKYMVm to dextran sodium sulfate (DSS)-treated mice reversed decreases in body weight, bleeding score and stool score in addition to reversing DSS-induced mucosa destruction and shortened colon. The WKYMVm-induced therapeutic effect against ulcerative colitis was strongly inhibited by a formyl peptide receptor (FPR) 2 antagonist, WRWWWW, indicating the crucial role of FPR2 in this effect. Mechanistically, WKYMVm effectively decreases intestinal permeability by stimulating colon epithelial cell proliferation. WKYMVm also strongly decreases interleukin-23 and transforming growth factor-β production in the colon of DSS-treated mice. We suggest that the potent immune-modulating peptide WKYMVm and its receptor FPR2 may be useful in the development of efficient therapeutic agents against chronic intestinal inflammatory diseases.

Original language	English
Article number	e40
Journal	Experimental and Molecular Medicine
Volume	45
Issue number	9
DOIs	https://doi.org/10.1038/emm.2013.77
State	Published - 2013.09

Keywords

Therapeutics
Ulcerative colitis
WKYMVm

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@article{31b0296530e047c38ca1ab92e4945c58,

title = "The immune-stimulating peptide WKYMVm has therapeutic effects against ulcerative colitis",

abstract = "In this study, we examined the therapeutic effects of an immune-stimulating peptide, WKYMVm, in ulcerative colitis. The administration of WKYMVm to dextran sodium sulfate (DSS)-treated mice reversed decreases in body weight, bleeding score and stool score in addition to reversing DSS-induced mucosa destruction and shortened colon. The WKYMVm-induced therapeutic effect against ulcerative colitis was strongly inhibited by a formyl peptide receptor (FPR) 2 antagonist, WRWWWW, indicating the crucial role of FPR2 in this effect. Mechanistically, WKYMVm effectively decreases intestinal permeability by stimulating colon epithelial cell proliferation. WKYMVm also strongly decreases interleukin-23 and transforming growth factor-β production in the colon of DSS-treated mice. We suggest that the potent immune-modulating peptide WKYMVm and its receptor FPR2 may be useful in the development of efficient therapeutic agents against chronic intestinal inflammatory diseases.",

keywords = "Therapeutics, Ulcerative colitis, WKYMVm",

author = "Kim, \{Sang Doo\} and Soonil Kwon and Lee, \{Sung Kyun\} and Minsoo Kook and Lee, \{Ha Young\} and Song, \{Ki Duk\} and Lee, \{Hak Kyo\} and Baek, \{Suk Hwan\} and Park, \{Chan Bae\} and Bae, \{Yoe Sik\}",

year = "2013",

month = sep,

doi = "10.1038/emm.2013.77",

language = "English",

volume = "45",

journal = "Experimental and Molecular Medicine",

issn = "1226-3613",

number = "9",

}

TY - JOUR

T1 - The immune-stimulating peptide WKYMVm has therapeutic effects against ulcerative colitis

AU - Kim, Sang Doo

AU - Kwon, Soonil

AU - Lee, Sung Kyun

AU - Kook, Minsoo

AU - Lee, Ha Young

AU - Song, Ki Duk

AU - Lee, Hak Kyo

AU - Baek, Suk Hwan

AU - Park, Chan Bae

AU - Bae, Yoe Sik

PY - 2013/9

Y1 - 2013/9

N2 - In this study, we examined the therapeutic effects of an immune-stimulating peptide, WKYMVm, in ulcerative colitis. The administration of WKYMVm to dextran sodium sulfate (DSS)-treated mice reversed decreases in body weight, bleeding score and stool score in addition to reversing DSS-induced mucosa destruction and shortened colon. The WKYMVm-induced therapeutic effect against ulcerative colitis was strongly inhibited by a formyl peptide receptor (FPR) 2 antagonist, WRWWWW, indicating the crucial role of FPR2 in this effect. Mechanistically, WKYMVm effectively decreases intestinal permeability by stimulating colon epithelial cell proliferation. WKYMVm also strongly decreases interleukin-23 and transforming growth factor-β production in the colon of DSS-treated mice. We suggest that the potent immune-modulating peptide WKYMVm and its receptor FPR2 may be useful in the development of efficient therapeutic agents against chronic intestinal inflammatory diseases.

AB - In this study, we examined the therapeutic effects of an immune-stimulating peptide, WKYMVm, in ulcerative colitis. The administration of WKYMVm to dextran sodium sulfate (DSS)-treated mice reversed decreases in body weight, bleeding score and stool score in addition to reversing DSS-induced mucosa destruction and shortened colon. The WKYMVm-induced therapeutic effect against ulcerative colitis was strongly inhibited by a formyl peptide receptor (FPR) 2 antagonist, WRWWWW, indicating the crucial role of FPR2 in this effect. Mechanistically, WKYMVm effectively decreases intestinal permeability by stimulating colon epithelial cell proliferation. WKYMVm also strongly decreases interleukin-23 and transforming growth factor-β production in the colon of DSS-treated mice. We suggest that the potent immune-modulating peptide WKYMVm and its receptor FPR2 may be useful in the development of efficient therapeutic agents against chronic intestinal inflammatory diseases.

KW - Therapeutics

KW - Ulcerative colitis

KW - WKYMVm

UR - https://www.scopus.com/pages/publications/84885140842

U2 - 10.1038/emm.2013.77

DO - 10.1038/emm.2013.77

M3 - Journal article

C2 - 24030327

AN - SCOPUS:84885140842

SN - 1226-3613

VL - 45

JO - Experimental and Molecular Medicine

JF - Experimental and Molecular Medicine

IS - 9

M1 - e40

ER -

The immune-stimulating peptide WKYMVm has therapeutic effects against ulcerative colitis

Abstract

Keywords

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