The structural shift of a DNA template between a hairpin and a dimer tunes the emission color of DNA-templated AgNCs

Pratik Shah; Suk Won Choi; Riddhi Nagda; Reka Geczy; Seok Keun Cho; Yong Joo Bhang; Tae Hwan Kim; Tae Yang Song; Phil Hyu Lee; Ju Hee Kang; Peter Waaben Thulstrup; Morten Jannik Bjerrum; Il Lae Jung; Seong Wook Yang

doi:10.1039/c8nr06186f

The structural shift of a DNA template between a hairpin and a dimer tunes the emission color of DNA-templated AgNCs

Pratik Shah
, Suk Won Choi
, Riddhi Nagda
, Reka Geczy
, Seok Keun Cho
, Yong Joo Bhang
, Tae Hwan Kim
, Tae Yang Song
, Phil Hyu Lee
, Ju Hee Kang
, Peter Waaben Thulstrup
, Morten Jannik Bjerrum
, Il Lae Jung^*
, Seong Wook Yang

^*Corresponding author for this work

Department of Quantum System Engineering

Yonsei University
University of Copenhagen
Seoulin Bioscience Co. Ltd.
Inha University
Korea Atomic Energy Research Institute

Research output: Contribution to journal › Journal article › peer-review

27 Scopus citations

Abstract

The scaffolding DNA sequence and the size of silver nanoclusters (AgNCs), confined in a DNA template are the key parameters in determining the fluorescent properties of DNA-stabilized silver nanoclusters (DNA/AgNCs). In addition, we suggest here that the structural shift of a DNA hairpin-dimer is as important as the DNA sequence in determining the emission wavelength of DNA/AgNCs. Furthermore, we show that the structural shift post AgNC formation can be triggered by incubation time and pre-AgNC formation under salt conditions. As an important factor in predicting the emission properties of DNA/AgNCs, the modulation of DNA secondary structures with either sequence changes or ionic conditions can be applied for the dual-color detection system of a target molecule. Particularly, the dual-color detection method may increase the reliability of DNA/AgNC sensors for miRNAs.

Original language	English
Pages (from-to)	20717-20722
Number of pages	6
Journal	Nanoscale
Volume	10
Issue number	44
DOIs	https://doi.org/10.1039/c8nr06186f
State	Published - 2018.11.28

Quacquarelli Symonds(QS) Subject Topics

Materials Science

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10.1039/c8nr06186f

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Shah, P., Choi, S. W., Nagda, R., Geczy, R., Cho, S. K., Bhang, Y. J., Kim, T. H., Song, T. Y., Lee, P. H., Kang, J. H., Thulstrup, P. W., Bjerrum, M. J., Jung, I. L., & Yang, S. W. (2018). The structural shift of a DNA template between a hairpin and a dimer tunes the emission color of DNA-templated AgNCs. Nanoscale, 10(44), 20717-20722. https://doi.org/10.1039/c8nr06186f

@article{4cc1ef9a0cfa45098a36d02eb9b66ca7,

title = "The structural shift of a DNA template between a hairpin and a dimer tunes the emission color of DNA-templated AgNCs",

abstract = "The scaffolding DNA sequence and the size of silver nanoclusters (AgNCs), confined in a DNA template are the key parameters in determining the fluorescent properties of DNA-stabilized silver nanoclusters (DNA/AgNCs). In addition, we suggest here that the structural shift of a DNA hairpin-dimer is as important as the DNA sequence in determining the emission wavelength of DNA/AgNCs. Furthermore, we show that the structural shift post AgNC formation can be triggered by incubation time and pre-AgNC formation under salt conditions. As an important factor in predicting the emission properties of DNA/AgNCs, the modulation of DNA secondary structures with either sequence changes or ionic conditions can be applied for the dual-color detection system of a target molecule. Particularly, the dual-color detection method may increase the reliability of DNA/AgNC sensors for miRNAs.",

author = "Pratik Shah and Choi, \{Suk Won\} and Riddhi Nagda and Reka Geczy and Cho, \{Seok Keun\} and Bhang, \{Yong Joo\} and Kim, \{Tae Hwan\} and Song, \{Tae Yang\} and Lee, \{Phil Hyu\} and Kang, \{Ju Hee\} and Thulstrup, \{Peter Waaben\} and Bjerrum, \{Morten Jannik\} and Jung, \{Il Lae\} and Yang, \{Seong Wook\}",

note = "Publisher Copyright: {\textcopyright} 2018 The Royal Society of Chemistry.",

year = "2018",

month = nov,

day = "28",

doi = "10.1039/c8nr06186f",

language = "English",

volume = "10",

pages = "20717--20722",

journal = "Nanoscale",

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TY - JOUR

T1 - The structural shift of a DNA template between a hairpin and a dimer tunes the emission color of DNA-templated AgNCs

AU - Shah, Pratik

AU - Choi, Suk Won

AU - Nagda, Riddhi

AU - Geczy, Reka

AU - Cho, Seok Keun

AU - Bhang, Yong Joo

AU - Kim, Tae Hwan

AU - Song, Tae Yang

AU - Lee, Phil Hyu

AU - Kang, Ju Hee

AU - Thulstrup, Peter Waaben

AU - Bjerrum, Morten Jannik

AU - Jung, Il Lae

AU - Yang, Seong Wook

PY - 2018/11/28

Y1 - 2018/11/28

N2 - The scaffolding DNA sequence and the size of silver nanoclusters (AgNCs), confined in a DNA template are the key parameters in determining the fluorescent properties of DNA-stabilized silver nanoclusters (DNA/AgNCs). In addition, we suggest here that the structural shift of a DNA hairpin-dimer is as important as the DNA sequence in determining the emission wavelength of DNA/AgNCs. Furthermore, we show that the structural shift post AgNC formation can be triggered by incubation time and pre-AgNC formation under salt conditions. As an important factor in predicting the emission properties of DNA/AgNCs, the modulation of DNA secondary structures with either sequence changes or ionic conditions can be applied for the dual-color detection system of a target molecule. Particularly, the dual-color detection method may increase the reliability of DNA/AgNC sensors for miRNAs.

AB - The scaffolding DNA sequence and the size of silver nanoclusters (AgNCs), confined in a DNA template are the key parameters in determining the fluorescent properties of DNA-stabilized silver nanoclusters (DNA/AgNCs). In addition, we suggest here that the structural shift of a DNA hairpin-dimer is as important as the DNA sequence in determining the emission wavelength of DNA/AgNCs. Furthermore, we show that the structural shift post AgNC formation can be triggered by incubation time and pre-AgNC formation under salt conditions. As an important factor in predicting the emission properties of DNA/AgNCs, the modulation of DNA secondary structures with either sequence changes or ionic conditions can be applied for the dual-color detection system of a target molecule. Particularly, the dual-color detection method may increase the reliability of DNA/AgNC sensors for miRNAs.

UR - https://www.scopus.com/pages/publications/85056671966

U2 - 10.1039/c8nr06186f

DO - 10.1039/c8nr06186f

M3 - Journal article

C2 - 30398269

AN - SCOPUS:85056671966

SN - 2040-3364

VL - 10

SP - 20717

EP - 20722

JO - Nanoscale

JF - Nanoscale

IS - 44

ER -

The structural shift of a DNA template between a hairpin and a dimer tunes the emission color of DNA-templated AgNCs

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