Therapeutic effects of adipose-derived mesenchymal stem cells combined with glymphatic system activation in prion disease

Mohammed Zayed; Yong Chan Kim; Byung Hoon Jeong

doi:10.1186/s13024-025-00835-y

Therapeutic effects of adipose-derived mesenchymal stem cells combined with glymphatic system activation in prion disease

Mohammed Zayed
, Yong Chan Kim
, Byung Hoon Jeong^*

^*Corresponding author for this work

Korea Zoonosis Research Institute at Jeonbuk National University

Jeonbuk National University
Qena University
Andong National University
Gyeongkuk National University

Research output: Contribution to journal › Letter › peer-review

9 Scopus citations

Abstract

There is currently no effective therapy for prion diseases. The glymphatic system is an organized system of perivascular spaces that facilitates the removal of metabolic waste from the brain. This study demonstrates the therapeutic potential of a combination therapy of adipose-derived mesenchymal stem cells (AdMSCs) and a glymphatic system-activated drug, clonidine, against prion disease. The therapy has the potential to clear PrP^Sc accumulation, ameliorate astrocytosis, and prolong the survival time of ME7-infected mice.

Original language	English
Article number	42
Journal	Molecular Neurodegeneration
Volume	20
Issue number	1
DOIs	https://doi.org/10.1186/s13024-025-00835-y
State	Published - 2025.12

Quacquarelli Symonds(QS) Subject Topics

Medicine
Biological Sciences

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10.1186/s13024-025-00835-y

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title = "Therapeutic effects of adipose-derived mesenchymal stem cells combined with glymphatic system activation in prion disease",

abstract = "There is currently no effective therapy for prion diseases. The glymphatic system is an organized system of perivascular spaces that facilitates the removal of metabolic waste from the brain. This study demonstrates the therapeutic potential of a combination therapy of adipose-derived mesenchymal stem cells (AdMSCs) and a glymphatic system-activated drug, clonidine, against prion disease. The therapy has the potential to clear PrPSc accumulation, ameliorate astrocytosis, and prolong the survival time of ME7-infected mice.",

author = "Mohammed Zayed and Kim, \{Yong Chan\} and Jeong, \{Byung Hoon\}",

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AU - Zayed, Mohammed

AU - Kim, Yong Chan

AU - Jeong, Byung Hoon

PY - 2025/12

Y1 - 2025/12

N2 - There is currently no effective therapy for prion diseases. The glymphatic system is an organized system of perivascular spaces that facilitates the removal of metabolic waste from the brain. This study demonstrates the therapeutic potential of a combination therapy of adipose-derived mesenchymal stem cells (AdMSCs) and a glymphatic system-activated drug, clonidine, against prion disease. The therapy has the potential to clear PrPSc accumulation, ameliorate astrocytosis, and prolong the survival time of ME7-infected mice.

AB - There is currently no effective therapy for prion diseases. The glymphatic system is an organized system of perivascular spaces that facilitates the removal of metabolic waste from the brain. This study demonstrates the therapeutic potential of a combination therapy of adipose-derived mesenchymal stem cells (AdMSCs) and a glymphatic system-activated drug, clonidine, against prion disease. The therapy has the potential to clear PrPSc accumulation, ameliorate astrocytosis, and prolong the survival time of ME7-infected mice.

UR - https://www.scopus.com/pages/publications/105003193301

U2 - 10.1186/s13024-025-00835-y

DO - 10.1186/s13024-025-00835-y

M3 - Letter

C2 - 40247424

AN - SCOPUS:105003193301

SN - 1750-1326

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JO - Molecular Neurodegeneration

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ER -

Therapeutic effects of adipose-derived mesenchymal stem cells combined with glymphatic system activation in prion disease

Abstract

Quacquarelli Symonds(QS) Subject Topics

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