Thiotipin, a novel thiopeptide with a tipA promoter inducing activity produced by Streptomyces sp. DT31

Bong Sik Yun; Tomomi Hidaka; Kazuo Furihata; Haruo Seto

doi:10.1016/S0040-4020(01)85660-X

Thiotipin, a novel thiopeptide with a tipA promoter inducing activity produced by Streptomyces sp. DT31

Bong Sik Yun^*
, Tomomi Hidaka
, Kazuo Furihata
, Haruo Seto

^*Corresponding author for this work

Environmental Biotechnology

The University of Tokyo

Research output: Contribution to journal › Journal article › peer-review

21 Scopus citations

Abstract

Thiotipin was isolated from the mycelium of Streptomyces sp. DT31 as a tipA promoter inducing substance. Based on various NMR studies including ¹H-¹H COSY, HSQC, FG-HMBC, phase-sensitive ¹³C-decoupled HMBC (D-HMBC) and NOE, its structure was established as a thiopeptide with oxazoles, thiazoles and several modified amino acids. Minimum induction concentration of thiotipin for tipA promoter was 80 ng/ml.

Original language	English
Pages (from-to)	11659-11664
Number of pages	6
Journal	Tetrahedron
Volume	50
Issue number	40
DOIs	https://doi.org/10.1016/S0040-4020(01)85660-X
State	Published - 1994

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title = "Thiotipin, a novel thiopeptide with a tipA promoter inducing activity produced by Streptomyces sp. DT31",

abstract = "Thiotipin was isolated from the mycelium of Streptomyces sp. DT31 as a tipA promoter inducing substance. Based on various NMR studies including 1H-1H COSY, HSQC, FG-HMBC, phase-sensitive 13C-decoupled HMBC (D-HMBC) and NOE, its structure was established as a thiopeptide with oxazoles, thiazoles and several modified amino acids. Minimum induction concentration of thiotipin for tipA promoter was 80 ng/ml.",

author = "Yun, \{Bong Sik\} and Tomomi Hidaka and Kazuo Furihata and Haruo Seto",

year = "1994",

doi = "10.1016/S0040-4020(01)85660-X",

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volume = "50",

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journal = "Tetrahedron",

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TY - JOUR

T1 - Thiotipin, a novel thiopeptide with a tipA promoter inducing activity produced by Streptomyces sp. DT31

AU - Yun, Bong Sik

AU - Hidaka, Tomomi

AU - Furihata, Kazuo

AU - Seto, Haruo

PY - 1994

Y1 - 1994

N2 - Thiotipin was isolated from the mycelium of Streptomyces sp. DT31 as a tipA promoter inducing substance. Based on various NMR studies including 1H-1H COSY, HSQC, FG-HMBC, phase-sensitive 13C-decoupled HMBC (D-HMBC) and NOE, its structure was established as a thiopeptide with oxazoles, thiazoles and several modified amino acids. Minimum induction concentration of thiotipin for tipA promoter was 80 ng/ml.

AB - Thiotipin was isolated from the mycelium of Streptomyces sp. DT31 as a tipA promoter inducing substance. Based on various NMR studies including 1H-1H COSY, HSQC, FG-HMBC, phase-sensitive 13C-decoupled HMBC (D-HMBC) and NOE, its structure was established as a thiopeptide with oxazoles, thiazoles and several modified amino acids. Minimum induction concentration of thiotipin for tipA promoter was 80 ng/ml.

UR - https://www.scopus.com/pages/publications/0028085569

U2 - 10.1016/S0040-4020(01)85660-X

DO - 10.1016/S0040-4020(01)85660-X

M3 - Journal article

AN - SCOPUS:0028085569

SN - 0040-4020

VL - 50

SP - 11659

EP - 11664

JO - Tetrahedron

JF - Tetrahedron

IS - 40

ER -

Thiotipin, a novel thiopeptide with a tipA promoter inducing activity produced by Streptomyces sp. DT31

Abstract

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