Total synthesis of a new 7-deoxyidarubicinone derivative through the functionalization of an A-ring side chain

Young S. Rho; Hyun Kyoung Ko; Wan Joong Kim; Dong Jin Yoo; Heun Soo Kang

Total synthesis of a new 7-deoxyidarubicinone derivative through the functionalization of an A-ring side chain

Young S. Rho^*
, Hyun Kyoung Ko
, Wan Joong Kim
, Dong Jin Yoo
, Heun Soo Kang

^*Corresponding author for this work

Department of Biological Sciences

Jeonbuk National University
Seonam University
Metabolic Engineering Laboratories Co., Ltd.

Research output: Contribution to journal › Journal article › peer-review

10 Scopus citations

Abstract

A convenient total synthesis of a new 7-deoxyidarubicinone derivative 21, the aglycon of the anticancer antibiotic idarubicin analogue, is described. Key features of the synthesis are the Friedel-Crafts acylation and the functionalization of an A-ring side chain. A synthon 14 for the A and B rings was prepared from intermediate 6 in five steps.

Original language	English
Pages (from-to)	774-778
Number of pages	5
Journal	Bulletin of the Korean Chemical Society
Volume	21
Issue number	8
State	Published - 2000.08.20

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Quacquarelli Symonds(QS) Subject Topics

Chemistry

Cite this

@article{1b2e8eea262e407a90c9866d54333ac7,

title = "Total synthesis of a new 7-deoxyidarubicinone derivative through the functionalization of an A-ring side chain",

abstract = "A convenient total synthesis of a new 7-deoxyidarubicinone derivative 21, the aglycon of the anticancer antibiotic idarubicin analogue, is described. Key features of the synthesis are the Friedel-Crafts acylation and the functionalization of an A-ring side chain. A synthon 14 for the A and B rings was prepared from intermediate 6 in five steps.",

author = "Rho, \{Young S.\} and Ko, \{Hyun Kyoung\} and Kim, \{Wan Joong\} and Yoo, \{Dong Jin\} and Kang, \{Heun Soo\}",

year = "2000",

month = aug,

day = "20",

language = "English",

volume = "21",

pages = "774--778",

journal = "Bulletin of the Korean Chemical Society",

issn = "0253-2964",

number = "8",

}

TY - JOUR

T1 - Total synthesis of a new 7-deoxyidarubicinone derivative through the functionalization of an A-ring side chain

AU - Rho, Young S.

AU - Ko, Hyun Kyoung

AU - Kim, Wan Joong

AU - Yoo, Dong Jin

AU - Kang, Heun Soo

PY - 2000/8/20

Y1 - 2000/8/20

N2 - A convenient total synthesis of a new 7-deoxyidarubicinone derivative 21, the aglycon of the anticancer antibiotic idarubicin analogue, is described. Key features of the synthesis are the Friedel-Crafts acylation and the functionalization of an A-ring side chain. A synthon 14 for the A and B rings was prepared from intermediate 6 in five steps.

AB - A convenient total synthesis of a new 7-deoxyidarubicinone derivative 21, the aglycon of the anticancer antibiotic idarubicin analogue, is described. Key features of the synthesis are the Friedel-Crafts acylation and the functionalization of an A-ring side chain. A synthon 14 for the A and B rings was prepared from intermediate 6 in five steps.

UR - https://www.scopus.com/pages/publications/0034692106

M3 - Journal article

AN - SCOPUS:0034692106

SN - 0253-2964

VL - 21

SP - 774

EP - 778

JO - Bulletin of the Korean Chemical Society

JF - Bulletin of the Korean Chemical Society

IS - 8

ER -

Total synthesis of a new 7-deoxyidarubicinone derivative through the functionalization of an A-ring side chain

Abstract

UN SDGs

Quacquarelli Symonds(QS) Subject Topics

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