Treatment of obesity with the resveratrol-enriched rice DJ-526

So Hyeon Baek; Hea Jong Chung; Heui Kwan Lee; Roshan D'Souza; Youngju Jeon; Hyeon Jin Kim; Soon Jong Kweon; Seong Tshool Hong

doi:10.1038/srep03879

Treatment of obesity with the resveratrol-enriched rice DJ-526

So Hyeon Baek
, Hea Jong Chung
, Heui Kwan Lee
, Roshan D'Souza
, Youngju Jeon
, Hyeon Jin Kim
, Soon Jong Kweon
, Seong Tshool Hong^*

^*Corresponding author for this work

Department of Medicine

Rural Development Administration
Jeonbuk National University
Jinis Biopharmaceuticals Inc.

Research output: Contribution to journal › Journal article › peer-review

46 Scopus citations

Abstract

Obesity is the most prevalent disease in the world which poses a serious risk for various chronic diseases. However, currently there are not any therapeutic agents that reduce body weight without causing serious side effects. In order to prevent and/or treat obesity and related diseases through a nutraceutical approach, we created a resveratrol-enriched transgenic rice accumulating 1.4â€...μg/g of resveratrol in its grain, DJ-526. Feeding of mice with the resveratrol-enriched rice DJ-526 showed excellent anti-obesity effect with reduction of body weights and abdominal fat volumes compared to the control by 20.0% and 31.3%, respectively. Also, the consumption of the resveratrol-enriched rice DJ526 significantly improved the blood lipid profiles and glucose levels in the animal experiments. Our resveratrol-enriched rice DJ-526 rice could provide both safe and convenient way for people with obesity and related diseases without major change of lifestyle or unwanted side effects from medication.

Original language	English
Article number	3879
Journal	Scientific Reports
Volume	4
DOIs	https://doi.org/10.1038/srep03879
State	Published - 2014.01.27

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1038/srep03879

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title = "Treatment of obesity with the resveratrol-enriched rice DJ-526",

abstract = "Obesity is the most prevalent disease in the world which poses a serious risk for various chronic diseases. However, currently there are not any therapeutic agents that reduce body weight without causing serious side effects. In order to prevent and/or treat obesity and related diseases through a nutraceutical approach, we created a resveratrol-enriched transgenic rice accumulating 1.4{\^a}€...μg/g of resveratrol in its grain, DJ-526. Feeding of mice with the resveratrol-enriched rice DJ-526 showed excellent anti-obesity effect with reduction of body weights and abdominal fat volumes compared to the control by 20.0\% and 31.3\%, respectively. Also, the consumption of the resveratrol-enriched rice DJ526 significantly improved the blood lipid profiles and glucose levels in the animal experiments. Our resveratrol-enriched rice DJ-526 rice could provide both safe and convenient way for people with obesity and related diseases without major change of lifestyle or unwanted side effects from medication.",

author = "Baek, \{So Hyeon\} and Chung, \{Hea Jong\} and Lee, \{Heui Kwan\} and Roshan D'Souza and Youngju Jeon and Kim, \{Hyeon Jin\} and Kweon, \{Soon Jong\} and Hong, \{Seong Tshool\}",

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AU - Baek, So Hyeon

AU - Chung, Hea Jong

AU - Lee, Heui Kwan

AU - D'Souza, Roshan

AU - Jeon, Youngju

AU - Kim, Hyeon Jin

AU - Kweon, Soon Jong

AU - Hong, Seong Tshool

PY - 2014/1/27

Y1 - 2014/1/27

N2 - Obesity is the most prevalent disease in the world which poses a serious risk for various chronic diseases. However, currently there are not any therapeutic agents that reduce body weight without causing serious side effects. In order to prevent and/or treat obesity and related diseases through a nutraceutical approach, we created a resveratrol-enriched transgenic rice accumulating 1.4â€...μg/g of resveratrol in its grain, DJ-526. Feeding of mice with the resveratrol-enriched rice DJ-526 showed excellent anti-obesity effect with reduction of body weights and abdominal fat volumes compared to the control by 20.0% and 31.3%, respectively. Also, the consumption of the resveratrol-enriched rice DJ526 significantly improved the blood lipid profiles and glucose levels in the animal experiments. Our resveratrol-enriched rice DJ-526 rice could provide both safe and convenient way for people with obesity and related diseases without major change of lifestyle or unwanted side effects from medication.

AB - Obesity is the most prevalent disease in the world which poses a serious risk for various chronic diseases. However, currently there are not any therapeutic agents that reduce body weight without causing serious side effects. In order to prevent and/or treat obesity and related diseases through a nutraceutical approach, we created a resveratrol-enriched transgenic rice accumulating 1.4â€...μg/g of resveratrol in its grain, DJ-526. Feeding of mice with the resveratrol-enriched rice DJ-526 showed excellent anti-obesity effect with reduction of body weights and abdominal fat volumes compared to the control by 20.0% and 31.3%, respectively. Also, the consumption of the resveratrol-enriched rice DJ526 significantly improved the blood lipid profiles and glucose levels in the animal experiments. Our resveratrol-enriched rice DJ-526 rice could provide both safe and convenient way for people with obesity and related diseases without major change of lifestyle or unwanted side effects from medication.

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Treatment of obesity with the resveratrol-enriched rice DJ-526

Abstract

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