Two novel furan derivatives from Phellinus linteus with anti-complement activity

Byung Sun Min; Bong Sik Yun; Hyeong Kyu Lee; Hee Jin Jung; Hyun Ah Jung; Jae Sue Choi

doi:10.1016/j.bmcl.2006.03.027

Two novel furan derivatives from Phellinus linteus with anti-complement activity

Byung Sun Min
, Bong Sik Yun
, Hyeong Kyu Lee
, Hee Jin Jung
, Hyun Ah Jung
, Jae Sue Choi^*

^*Corresponding author for this work

Catholic University of Daegu
Korea Research Institute of Bioscience and Biotechnology
Pukyong National University

Research output: Contribution to journal › Journal article › peer-review

27 Scopus citations

Abstract

Two novel stereoisomers of furan derivatives, phellinusfurans A (1) and B (2), were isolated from the fruiting body of Phellinus linteus. Their structures were elucidated by spectroscopic analysis. Compounds 1 and 2 exhibited significant anti-complement activity with IC₅₀ values of 33.6 and 33.7 μM, respectively, in inhibiting the hemolytic activity of human serum against erythrocytes.

Original language	English
Pages (from-to)	3255-3257
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	16
Issue number	12
DOIs	https://doi.org/10.1016/j.bmcl.2006.03.027
State	Published - 2006.06.15

Keywords

Anti-complement activity
Furan derivatives
Phellinus linteus
Structural determination

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10.1016/j.bmcl.2006.03.027

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@article{41202ffe507c46c3aefa46bccfd34288,

title = "Two novel furan derivatives from Phellinus linteus with anti-complement activity",

abstract = "Two novel stereoisomers of furan derivatives, phellinusfurans A (1) and B (2), were isolated from the fruiting body of Phellinus linteus. Their structures were elucidated by spectroscopic analysis. Compounds 1 and 2 exhibited significant anti-complement activity with IC50 values of 33.6 and 33.7 μM, respectively, in inhibiting the hemolytic activity of human serum against erythrocytes.",

keywords = "Anti-complement activity, Furan derivatives, Phellinus linteus, Structural determination",

author = "Min, \{Byung Sun\} and Yun, \{Bong Sik\} and Lee, \{Hyeong Kyu\} and Jung, \{Hee Jin\} and Jung, \{Hyun Ah\} and Choi, \{Jae Sue\}",

year = "2006",

month = jun,

day = "15",

doi = "10.1016/j.bmcl.2006.03.027",

language = "English",

volume = "16",

pages = "3255--3257",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

number = "12",

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TY - JOUR

T1 - Two novel furan derivatives from Phellinus linteus with anti-complement activity

AU - Min, Byung Sun

AU - Yun, Bong Sik

AU - Lee, Hyeong Kyu

AU - Jung, Hee Jin

AU - Jung, Hyun Ah

AU - Choi, Jae Sue

PY - 2006/6/15

Y1 - 2006/6/15

N2 - Two novel stereoisomers of furan derivatives, phellinusfurans A (1) and B (2), were isolated from the fruiting body of Phellinus linteus. Their structures were elucidated by spectroscopic analysis. Compounds 1 and 2 exhibited significant anti-complement activity with IC50 values of 33.6 and 33.7 μM, respectively, in inhibiting the hemolytic activity of human serum against erythrocytes.

AB - Two novel stereoisomers of furan derivatives, phellinusfurans A (1) and B (2), were isolated from the fruiting body of Phellinus linteus. Their structures were elucidated by spectroscopic analysis. Compounds 1 and 2 exhibited significant anti-complement activity with IC50 values of 33.6 and 33.7 μM, respectively, in inhibiting the hemolytic activity of human serum against erythrocytes.

KW - Anti-complement activity

KW - Furan derivatives

KW - Phellinus linteus

KW - Structural determination

UR - https://www.scopus.com/pages/publications/33646167629

U2 - 10.1016/j.bmcl.2006.03.027

DO - 10.1016/j.bmcl.2006.03.027

M3 - Journal article

C2 - 16581246

AN - SCOPUS:33646167629

SN - 0960-894X

VL - 16

SP - 3255

EP - 3257

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 12

ER -

Two novel furan derivatives from Phellinus linteus with anti-complement activity

Abstract

Keywords

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