Understanding the Antifungal Mechanism of Ag@ZnO Core-shell Nanocomposites against Candida krusei

Bhaskar Das; Md Imran Khan; R. Jayabalan; Susanta K. Behera; Soon Il Yun; Suraj K. Tripathy; Amrita Mishra

doi:10.1038/srep36403

Understanding the Antifungal Mechanism of Ag@ZnO Core-shell Nanocomposites against Candida krusei

Bhaskar Das
, Md Imran Khan
, R. Jayabalan
, Susanta K. Behera
, Soon Il Yun
, Suraj K. Tripathy
, Amrita Mishra^*

^*Corresponding author for this work

Department of Food Science and Technology

Kalinga Institute of Industrial Technology
National Institute of Technology Rourkela
IMGENEX India Pvt. Ltd.

Research output: Contribution to journal › Journal article › peer-review

93 Scopus citations

Abstract

In the present paper, facile synthesis of Ag@ZnO core-shell nanocomposites is reported where zinc oxide is coated on biogenic silver nanoparticles synthesized using Andrographis paniculata and Aloe vera leaf extract. Structural features of as synthesized nanocomposites are characterized by UV-visible spectroscopy, XRD, and FTIR. Morphology of the above core-shell nanocomposites is investigated by electron microscopy. As synthesized nanocomposite material has shown antimicrobial activity against Candida krusei, which is an opportunistic pathogen known to cause candidemia. The possible mode of activity of the above material has been studied by in-vitro molecular techniques. Our investigations have shown that surface coating of biogenic silver nanoparticles by zinc oxide has increased its antimicrobial efficiency against Candida krusei, while decreasing its toxicity towards A431 human epidermoid carcinoma cell lines.

Original language	English
Article number	36403
Journal	Scientific Reports
Volume	6
DOIs	https://doi.org/10.1038/srep36403
State	Published - 2016.11.4

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title = "Understanding the Antifungal Mechanism of Ag@ZnO Core-shell Nanocomposites against Candida krusei",

abstract = "In the present paper, facile synthesis of Ag@ZnO core-shell nanocomposites is reported where zinc oxide is coated on biogenic silver nanoparticles synthesized using Andrographis paniculata and Aloe vera leaf extract. Structural features of as synthesized nanocomposites are characterized by UV-visible spectroscopy, XRD, and FTIR. Morphology of the above core-shell nanocomposites is investigated by electron microscopy. As synthesized nanocomposite material has shown antimicrobial activity against Candida krusei, which is an opportunistic pathogen known to cause candidemia. The possible mode of activity of the above material has been studied by in-vitro molecular techniques. Our investigations have shown that surface coating of biogenic silver nanoparticles by zinc oxide has increased its antimicrobial efficiency against Candida krusei, while decreasing its toxicity towards A431 human epidermoid carcinoma cell lines.",

author = "Bhaskar Das and Khan, \{Md Imran\} and R. Jayabalan and Behera, \{Susanta K.\} and Yun, \{Soon Il\} and Tripathy, \{Suraj K.\} and Amrita Mishra",

note = "Publisher Copyright: {\textcopyright} 2016 The Author(s).",

year = "2016",

month = nov,

day = "4",

doi = "10.1038/srep36403",

language = "English",

volume = "6",

journal = "Scientific Reports",

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T1 - Understanding the Antifungal Mechanism of Ag@ZnO Core-shell Nanocomposites against Candida krusei

AU - Das, Bhaskar

AU - Khan, Md Imran

AU - Jayabalan, R.

AU - Behera, Susanta K.

AU - Yun, Soon Il

AU - Tripathy, Suraj K.

AU - Mishra, Amrita

PY - 2016/11/4

Y1 - 2016/11/4

N2 - In the present paper, facile synthesis of Ag@ZnO core-shell nanocomposites is reported where zinc oxide is coated on biogenic silver nanoparticles synthesized using Andrographis paniculata and Aloe vera leaf extract. Structural features of as synthesized nanocomposites are characterized by UV-visible spectroscopy, XRD, and FTIR. Morphology of the above core-shell nanocomposites is investigated by electron microscopy. As synthesized nanocomposite material has shown antimicrobial activity against Candida krusei, which is an opportunistic pathogen known to cause candidemia. The possible mode of activity of the above material has been studied by in-vitro molecular techniques. Our investigations have shown that surface coating of biogenic silver nanoparticles by zinc oxide has increased its antimicrobial efficiency against Candida krusei, while decreasing its toxicity towards A431 human epidermoid carcinoma cell lines.

AB - In the present paper, facile synthesis of Ag@ZnO core-shell nanocomposites is reported where zinc oxide is coated on biogenic silver nanoparticles synthesized using Andrographis paniculata and Aloe vera leaf extract. Structural features of as synthesized nanocomposites are characterized by UV-visible spectroscopy, XRD, and FTIR. Morphology of the above core-shell nanocomposites is investigated by electron microscopy. As synthesized nanocomposite material has shown antimicrobial activity against Candida krusei, which is an opportunistic pathogen known to cause candidemia. The possible mode of activity of the above material has been studied by in-vitro molecular techniques. Our investigations have shown that surface coating of biogenic silver nanoparticles by zinc oxide has increased its antimicrobial efficiency against Candida krusei, while decreasing its toxicity towards A431 human epidermoid carcinoma cell lines.

UR - https://www.scopus.com/pages/publications/84994626956

U2 - 10.1038/srep36403

DO - 10.1038/srep36403

M3 - Journal article

C2 - 27812015

AN - SCOPUS:84994626956

SN - 2045-2322

VL - 6

JO - Scientific Reports

JF - Scientific Reports

M1 - 36403

ER -

Understanding the Antifungal Mechanism of Ag@ZnO Core-shell Nanocomposites against Candida krusei

Abstract

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