Visible-Light-Driven Sulfonamidation of Arylazo Sulfonesthrough One-Pot Multicomponent Reaction

Sulfonamide is one of the most important structures in organic chemistry due to its frequent appearance in natural products as well as pharmaceuticals. This study reports a visible-light-promoted strategy for synthesis of sulfonamides from arylazo sulfones. One-pot tri-component reactions were conducted using arylazo sulfones, DABSO, and amines in the presence of CuBr₂ as a coupling catalyst under irradiation with blue LEDs to prepare various sulfonamides in good yields under mild conditions. This method could be used effectively to produce a variety of useful sulfonamides.