Abstract
Aim: This study investigated whether a keratin hydrogel derived from wool enhances ossointegration of dental implants, using a cancellous bone model in sheep. Method: Ten female sheep received one dental implant per hind leg in the distal femoral condyles. Test implants were coated with 1 mL of keratin hydrogel containing sulphonated keratin and hydroxyapatite; control implants remained uncoated; implants were not functionally loaded axially. Biomechanical stability was tested with resonance frequency analysis (RFA) at placement and euthanasia. Animals were sacrificed after 4 weeks and resin-embedded histomorphometry performed. Findings: Bone appeared denser and more mature around the keratin-treated test implants. Average % bone–implant contact was significantly increased for the test (58.1 ± 4.6 [SD]%) compared to control implants (34.4 ± 7.5%) (p = 0.01). RFA values were lower for control (76.5 ± 4.2 ISQ) than test implants (80.4 ± 1.4) after 4 weeks (p = 0.04). Conclusion: the increase in osseointegration found in this model suggests that keratin hydrogel has the potential to enhance the successful osseointegration of dental implants placed into poor quality bone.
| Original language | English |
|---|---|
| Pages (from-to) | 2447-2454 |
| Number of pages | 8 |
| Journal | Journal of Biomedical Materials Research - Part B Applied Biomaterials |
| Volume | 106 |
| Issue number | 6 |
| DOIs | |
| State | Published - 2018.08 |
Keywords
- animal models
- dental implants
- histomorphometric
- keratins
- osseointegration
Quacquarelli Symonds(QS) Subject Topics
- Materials Science
- Biological Sciences
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